Leong A S, Gilham P, Milios J
Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia.
Histopathology. 1988 Oct;13(4):435-42. doi: 10.1111/j.1365-2559.1988.tb02059.x.
Prostatic samples from 30 hyperplastic prostates and 61 prostatic adenocarcinomas were examined for vimentin and cytokeratins. The co-expression of cytokeratins and vimentin was found in all benign prostatic epithelium and in 83% of adenocarcinomas. Benign prostatic epithelium showed vimentin intermediate filaments distinctively distributed in the basal regions and as paranuclear sheaves along the long axis of the cell. This pattern of vimentin staining was seen in adenocarcinomas with low Gleason scores, whereas high-grade tumours showed intense diffuse perinuclear staining.
对30个增生性前列腺组织样本和61个前列腺腺癌组织样本进行波形蛋白和细胞角蛋白检测。在所有良性前列腺上皮以及83%的腺癌组织中均发现细胞角蛋白和波形蛋白共表达。良性前列腺上皮中波形蛋白中间丝在基底区域呈独特分布，并沿细胞长轴呈核旁束状分布。这种波形蛋白染色模式在Gleason评分较低的腺癌组织中可见，而高级别肿瘤则表现为强烈的弥漫性核周染色。
