Płaczek Margin, Jacyna Julia, Sznitowska Małgorzata
Pol Merkur Lekarski. 2014 Jan;36(211):54-8.
Microspheres and implants are injectable drug forms, which by special design and selection of appropriate excipients, provide for a long time constant release rate of an active substance in the body. Development of both would not be possible without advances in polymer technology and invention of safe and biocompatible polymers such as: polyesters, vinyl acetate derivatives or silicones. Polymeric matrices provide retardation of drug release--for some implants up to a few years. In addition, this paper presents examples of all commercially available medicinal products containing microspheres and implants, currently registered in Poland, together with their characteristics: composition, time course and frequency of administration. Comments are also enclosed on frequently occurring inconsistent terminology in pharmaceutical forms.
微球和植入剂是可注射的药物剂型，通过特殊设计和选择合适的辅料，可使活性物质在体内长时间以恒定速率释放。如果没有聚合物技术的进步以及安全且生物相容性良好的聚合物（如聚酯、醋酸乙烯酯衍生物或硅酮）的发明，这两种剂型的开发都将无法实现。聚合物基质可延缓药物释放——对于某些植入剂而言，长达数年。此外，本文还列举了目前在波兰注册的所有含有微球和植入剂的市售药品实例及其特性：组成、给药时间过程和频率。文中还对药物剂型中常见的不一致术语进行了评论。
