Shi Yi, Li Luk Chiu
Abbott Laboratories, Global Pharmaceutical Research & Development, Abbott Park, IL 60064, USA.
Expert Opin Drug Deliv. 2005 Nov;2(6):1039-58. doi: 10.1517/17425247.2.6.1039.
Major progresses in the development of parenteral sustained-release systems have been made in recent years as evidenced by the regulatory approval and market launch of several new products. Both the availability of novel carrier materials and the advances in method of fabrication have contributed to these commercial successes. With the formulation challenges associated with biologics, new delivery systems have also been evolved specifically to address the unmet needs in the parenteral sustained release of proteins. In this review paper, different new carriers systems and preparation methods are discussed with special focus on their applications to biologicals.
近年来，胃肠外缓释系统的开发取得了重大进展，这从几种新产品的监管批准和市场推出中可见一斑。新型载体材料的可用性和制造方法的进步都促成了这些商业上的成功。鉴于生物制品相关的制剂挑战，还专门研发了新的递送系统，以满足蛋白质胃肠外缓释方面未得到满足的需求。在这篇综述论文中，将讨论不同的新型载体系统和制备方法，并特别关注它们在生物制品中的应用。
