铜催化的使用二甲基乙酰胺作为一碳源的苄基吡啶的α-亚甲基化反应。
Copper-catalyzed α-methylenation of benzylpyridines using dimethylacetamide as one-carbon source.
机构信息
Department of Applied Chemistry, Faculty of Engineering, Osaka University , Suita, Osaka 565-0871, Japan.
出版信息
Org Lett. 2014 Apr 4;16(7):2050-3. doi: 10.1021/ol500655k. Epub 2014 Mar 19.
PMID:24646166
Abstract
The direct α-methylenation of benzylpyridines was achieved using N,N-dimethylacetamide (DMA) as a one-carbon source under copper catalysis. An intermediary species was detected at an early stage, and a possible mechanism was proposed. Additionally, α-oxygenation and dimerization of benzylpyridines could also be performed efficiently.
摘要
在铜催化作用下，使用 N,N-二甲基乙酰胺（DMA）作为一碳源，实现了苯并吡啶的直接 α-亚甲基化。在早期阶段检测到一种中间体物种，并提出了一种可能的反应机制。此外，苯并吡啶的α-氧化和二聚化也能高效进行。
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