Martin Tamara P, Currie Susan, Baillie George S
*Institute of Cardiovascular and Medical Sciences, University of Glasgow, Wolfson-Link Building, Glasgow G12 8QQ, U.K.
†Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Hamnett Building, 161 Cathedral Street, Glasgow G4 0RE, U.K.
Biochem Soc Trans. 2014 Apr;42(2):270-3. doi: 10.1042/BST20130272.
The small HSP (heat-shock protein) HSP20 is a molecular chaperone that is transiently up-regulated in response to cellular stress/damage. Although ubiquitously expressed in various tissues, it is most highly expressed in skeletal, cardiac and smooth muscle. Phosphorylation at Ser16 by PKA (cAMP-dependent protein kinase) is essential for HSP20 to confer its protective qualities. HSP20 and its phosphorylation have been implicated in a variety of pathophysiological processes, but most prominently cardiovascular disease. A wealth of knowledge of the importance of HSP20 in contractile function and cardioprotection has been gained over the last decade. The present mini-review highlights more recent findings illustrating the cardioprotective properties of HSP20 and its potential as a therapeutic agent.
小分子热休克蛋白（HSP）HSP20是一种分子伴侣，在细胞应激/损伤时会短暂上调表达。尽管它在各种组织中普遍表达，但在骨骼肌、心肌和平滑肌中表达量最高。蛋白激酶A（PKA，环磷酸腺苷依赖性蛋白激酶）介导的丝氨酸16位点磷酸化对于HSP20发挥其保护作用至关重要。HSP20及其磷酸化作用涉及多种病理生理过程，其中最显著的是心血管疾病。在过去十年中，人们对HSP20在收缩功能和心脏保护方面的重要性有了丰富的认识。本综述重点介绍了有关HSP20心脏保护特性及其作为治疗药物潜力的最新研究发现。
