Charmpilas Nikolaos, Kyriakakis Emmanouil, Tavernarakis Nektarios
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 70013, Heraklion, Crete, Greece.
Department of Biology, University of Crete, 70013, Heraklion, Crete, Greece.
Cell Stress Chaperones. 2017 Jul;22(4):481-492. doi: 10.1007/s12192-016-0761-x. Epub 2017 Jan 10.
Small heat shock proteins (sHSPs) are gatekeepers of cellular homeostasis across species, preserving proteome integrity under stressful conditions. Nonetheless, recent evidence suggests that sHSPs are more than molecular chaperones with merely auxiliary role. In contrast, sHSPs have emerged as central lifespan determinants, and their malfunction has been associated with the manifestation of neurological disorders, cardiovascular disease and cancer malignancies. In this review, we focus on the role of sHSPs in ageing and age-associated diseases and highlight the most prominent paradigms, where impairment of sHSP function has been implicated in human pathology.
小分子热休克蛋白（sHSPs）是跨物种细胞稳态的守护者，在应激条件下维持蛋白质组的完整性。尽管如此，最近的证据表明，sHSPs不仅仅是具有辅助作用的分子伴侣。相反，sHSPs已成为寿命的核心决定因素，其功能失调与神经疾病、心血管疾病和癌症恶性肿瘤的表现有关。在这篇综述中，我们聚焦于sHSPs在衰老和年龄相关疾病中的作用，并强调了最突出的范例，即sHSP功能受损与人类病理学有关。
