Ramírez Huaranga Marco Aurelio, Bencosme de Mendez Erika, Cuadra Díaz José Luis, Lázaro Polo Javier, Bujalance Cabrera Carlos
Servicio de Reumatología, Hospital General Universitario de Ciudad Real, Ciudad Real, España.
Servicio de Medicina Interna, Hospital General Universitario de Ciudad Real, Ciudad Real, España.
Reumatol Clin. 2014 Sep-Oct;10(5):328-30. doi: 10.1016/j.reuma.2013.07.010. Epub 2014 Mar 16.
Although hypersensitivity pneumonitis is the most common pulmonary complication described during treatment with methotrexate, other complications like lymphoproliferative and infectious disease may be considered in the study of respiratory disease associated to methotrexate. The existence of an increased risk to developing infectious diseases may be similar to that observed during treatment with antagonists of tumor necrosis factor and corticosteroids, where Cytomegalovirus pneumonia is a serious complication; early diagnosis and treatment will prevent a potentially fatal outcome.
虽然超敏性肺炎是甲氨蝶呤治疗期间描述的最常见肺部并发症，但在研究与甲氨蝶呤相关的呼吸系统疾病时，也可能会考虑其他并发症，如淋巴增殖性疾病和感染性疾病。发生感染性疾病风险增加的情况可能与使用肿瘤坏死因子拮抗剂和皮质类固醇治疗期间观察到的情况类似，在后者中，巨细胞病毒肺炎是一种严重并发症；早期诊断和治疗可预防潜在的致命后果。
