Wang Ge, Peng Xiaoyan
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China.
J Ophthalmol. 2020 Aug 11;2020:1537689. doi: 10.1155/2020/1537689. eCollection 2020.
Methotrexate (MTX) is a folate analog widely used against a range of diseases including malignancies and autoimmune disorders. Its high effectiveness-price ratio also won extensive application in ophthalmology. On the other hand, although MTX has an excellent pharmacological efficacy, MTX associated side effects in clinical use, which vary from patient to patient, are nonnegligible. There is no comparatively systematic review on MTX associated side effects and its risk factors. This review aimed to reveal novel clinical approaches of MTX and its adverse effects in order to provide a reference for ophthalmic scholars in clinical application of MTX.
甲氨蝶呤（MTX）是一种叶酸类似物，广泛用于治疗包括恶性肿瘤和自身免疫性疾病在内的一系列疾病。其高效价比也使其在眼科领域得到广泛应用。另一方面，尽管MTX具有出色的药理功效，但MTX在临床使用中出现的副作用因人而异，不容忽视。目前尚无关于MTX相关副作用及其危险因素的较为系统的综述。本综述旨在揭示MTX的新临床应用方法及其不良反应，为眼科学者在MTX临床应用中提供参考。
