高级乳腺血管肉瘤对含吉西他滨的化疗完全有效。
Advanced breast angiosarcoma completely responding to gemcitabine-containing chemotherapy.
机构信息
Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China ; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
出版信息
Breast Care (Basel). 2012 Oct;7(5):414-6. doi: 10.1159/000343614.
BACKGROUND
For patients with anthracycline-resistant metastatic angiosarcoma, there is currently no available standard for second-line therapy, and a need exists for novel effective regimens to improve response rates.
CASE REPORT
We report here on a case of a primary angiosarcoma of both breasts in a 34-year-old woman presenting with lung metastases. Upon completion of 3 cycles of the MAID regimen (mesna, adriamycin, ifosfamide, dacarbazine), computed tomography showed disease progression. Subsequently, a second-line chemotherapy was started using the GVP regimen (gemcitabine, vincristine, cisplatin). Complete response of the lung metastases was achieved after 6 cycles of treatment.
CONCLUSION
In the absence of an effective therapy among patients with anthracycline-resistant metastatic breast angiosarcoma, a GVP chemotherapy regimen can be performed as a selective option.
背景
对于蒽环类耐药转移性血管肉瘤患者，目前尚无二线治疗的标准方案，需要新的有效方案来提高缓解率。
病例报告
我们在此报告一例 34 岁女性双侧原发性乳腺血管肉瘤病例，该患者表现为肺转移。完成 MAID 方案（美司钠、阿霉素、异环磷酰胺、达卡巴嗪）3 个周期后，CT 显示疾病进展。随后，二线化疗开始使用 GVP 方案（吉西他滨、长春新碱、顺铂）。治疗 6 个周期后，肺部转移完全缓解。
结论
在蒽环类耐药转移性乳腺血管肉瘤患者中，没有有效的治疗方法，GVP 化疗方案可以作为一种选择性方案。
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