Zhou Sheng-Ang, Wei Hongquan, Ding Kefeng
Department of Surgical Oncology, Education Ministry Key Laboratory of Cancer Prevention and Intervention, Second Affiliated Hospital of Zhejiang University School of Medicine, China.
Breast Care (Basel). 2009;4(6):405-407. doi: 10.1159/000261506. Epub 2009 Dec 15.
Primary angiosarcoma of the breast (PAB) is a rare occurrence of highly aggressive biological behavior. Bilateral PAB is even more infrequent. CASE REPORT: We present the case of a 39-year-old Chinese woman with metachronous bilateral PAB (2005 and 2008). The diagnosis of PAB was confirmed. The respective masses were removed via simple mastectomy. The extent of malignancy differed microscopically between the two tumors and indicated a different source. After two surgeries and a 3-year follow-up, the patient is alive and well. The current case illustrates an unusual presentation of this rare type of breast sarcoma, in that none of the clin-icopathological findings are thought to confer a good prognosis. We also review the literature and summarize relevant findings concerning definition, pathology, clinical features, treatment, and follow-up. CONCLUSIONS: We believe that the survival rate depends on tumor size and differentiation. Surgical resection followed by chemotherapy may prove to be effective and afford the best prognosis in the future.
原发性乳腺血管肉瘤（PAB）是一种罕见的具有高度侵袭性生物学行为的疾病。双侧PAB更为罕见。病例报告：我们报告一例39岁中国女性发生异时性双侧PAB（分别于2005年和2008年发病）的病例。PAB诊断得以确诊。通过单纯乳房切除术切除了相应肿块。两个肿瘤在显微镜下的恶性程度不同，提示来源不同。经过两次手术及3年随访，患者存活且状况良好。本病例说明了这种罕见类型乳腺肉瘤的一种不寻常表现，即没有任何临床病理特征被认为可带来良好预后。我们还回顾了文献并总结了有关定义、病理、临床特征、治疗及随访的相关发现。结论：我们认为生存率取决于肿瘤大小和分化程度。手术切除后进行化疗可能证明是有效的，并在未来提供最佳预后。
