易位项目：如何让好药作用于有害病菌。 - Suppr

TRANSLOCATION project: how to get good drugs into bad bugs.

作者信息

Stavenger Robert A, Winterhalter Mathias

机构信息

Robert A. Stavenger is Team Leader in the Antibacterial Discovery Performance Unit, GlaxoSmithKline, Collegeville, PA 19426, USA.

出版信息

Sci Transl Med. 2014 Mar 19;6(228):228ed7. doi: 10.1126/scitranslmed.3008605.

DOI:10.1126/scitranslmed.3008605

PMID:24648337

Abstract

摘要

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TRANSLOCATION project: how to get good drugs into bad bugs.易位项目：如何让好药作用于有害病菌。

Sci Transl Med. 2014 Mar 19;6(228):228ed7. doi: 10.1126/scitranslmed.3008605.

Intra-abdominal infections: do we need to change our antibiotic coverage in this era of Gram negative resistance?

J Assoc Physicians India. 2011 May;59:285.

Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement.革兰阴性菌所致医疗保健相关感染的治疗：共识声明

Lancet Infect Dis. 2008 Feb;8(2):133-9. doi: 10.1016/S1473-3099(08)70018-5.

Emerging resistance in Gram-negative pathogens and implications for clinical practice.革兰氏阴性病原体出现耐药性及其对临床实践的影响。

Future Microbiol. 2011 Jan;6(1):19-22. doi: 10.2217/fmb.10.150.

Continuous versus intermittent infusion of polymyxin B in the treatment of infections caused by multidrug-resistant Gram-negative bacteria.多粘菌素B持续输注与间歇输注治疗多重耐药革兰阴性菌感染的比较

Int J Antimicrob Agents. 2008 Jan;31(1):80-2. doi: 10.1016/j.ijantimicag.2007.08.004. Epub 2007 Oct 24.

Editorial comment.编者按。

Scand J Infect Dis. 2011 Mar;43(3):163-4. doi: 10.3109/00365548.2011.553840.

Antibiotic resistance. Nosocomial gram-negative infection.抗生素耐药性。医院获得性革兰氏阴性菌感染。

J Med Microbiol. 1997 Jun;46(6):436-9.

Bacterial resistance, beta-lactam antibiotics and gramnegative bacteria at ICUs.重症监护病房中的细菌耐药性、β-内酰胺类抗生素与革兰氏阴性菌

Wien Klin Wochenschr. 1999 Jul 30;111(14):537-8.

Use of colistin in children.黏菌素在儿童中的应用。

Pediatr Infect Dis J. 2009 Jun;28(6):534-5. doi: 10.1097/INF.0b013e3181ac4980.

Gram-negative superbugs: inappropriate antimicrobial therapy and mortality.革兰氏阴性超级细菌：不恰当的抗菌治疗与死亡率

Expert Rev Clin Pharmacol. 2013 Jul;6(4):347-9. doi: 10.1586/17512433.2013.811831.

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Electrophysiological Insights into Antibiotic Translocation and Resistance: The Impact of Outer Membrane Proteins.抗生素转运与耐药性的电生理学见解：外膜蛋白的影响

Membranes (Basel). 2024 Jul 20;14(7):161. doi: 10.3390/membranes14070161.

Design and synthesis of a library of C2-substituted sulfamidoadenosines to probe bacterial permeability.设计并合成 C2-取代磺酰胺腺苷文库以探测细菌通透性。

Bioorg Med Chem Lett. 2024 Jan 1;97:129486. doi: 10.1016/j.bmcl.2023.129486. Epub 2023 Sep 20.

Dynamic interaction of fluoroquinolones with magnesium ions monitored using bacterial outer membrane nanopores.利用细菌外膜纳米孔监测氟喹诺酮类药物与镁离子的动态相互作用。

Chem Sci. 2020 Aug 31;11(38):10344-10353. doi: 10.1039/d0sc03486j.

Electroosmosis Dominates Electrophoresis of Antibiotic Transport Across the Outer Membrane Porin F.电渗作用主导抗生素跨外膜孔蛋白F的电泳运输。

Biophys J. 2020 Jun 2;118(11):2844-2852. doi: 10.1016/j.bpj.2020.04.011. Epub 2020 Apr 19.

The challenge of intracellular antibiotic accumulation, a function of fluoroquinolone influx versus bacterial efflux.细胞内抗生素积累的挑战，这是氟喹诺酮类药物流入与细菌外排的功能。

Commun Biol. 2020 Apr 28;3(1):198. doi: 10.1038/s42003-020-0929-x.

Electrophysiological Characterization of Transport Across Outer-Membrane Channels from Gram-Negative Bacteria in Presence of Lipopolysaccharides.革兰氏阴性菌外膜通道在脂多糖存在下的转运的电生理学特性。

Angew Chem Int Ed Engl. 2020 May 25;59(22):8517-8521. doi: 10.1002/anie.201913618. Epub 2020 Mar 24.

Using Colistin as a Trojan Horse: Inactivation of Gram-Negative Bacteria with Chlorophyllin.将黏菌素用作特洛伊木马：用叶绿酸灭活革兰氏阴性菌。

Antibiotics (Basel). 2019 Sep 20;8(4):158. doi: 10.3390/antibiotics8040158.

Quantitative contribution of efflux to multi-drug resistance of clinical Escherichia coli and Pseudomonas aeruginosa strains.临床型大肠埃希菌和铜绿假单胞菌多重耐药中外排泵作用的定量贡献。

EBioMedicine. 2019 Mar;41:479-487. doi: 10.1016/j.ebiom.2019.02.061. Epub 2019 Mar 7.

Mechanistic aspects of maltotriose-conjugate translocation to the Gram-negative bacteria cytoplasm.麦芽糖三糖向革兰氏阴性菌细胞质的共轭转运的机制方面。

Life Sci Alliance. 2018 Dec 28;2(1):e201800242. doi: 10.26508/lsa.201800242. eCollection 2019 Feb.

Fosfomycin Permeation through the Outer Membrane Porin OmpF.磷霉素通过外膜孔蛋白 OmpF 的渗透。

Biophys J. 2019 Jan 22;116(2):258-269. doi: 10.1016/j.bpj.2018.12.002. Epub 2018 Dec 8.

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TRANSLOCATION project: how to get good drugs into bad bugs.

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