细胞死亡、血糖异常与心肌梗死。
Cell death, dysglycemia and myocardial infarction.
作者信息
Tian Xiao-Fang, Cui Ming-Xia, Yang Shi-Wei, Zhou Yu-Jie, Hu DA-Yi
机构信息
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Department of Pharmacology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu 730000;
12th Ward, Department of Cardiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, The Key Laboratory of Remodeling-Related Cardiovascular Disease, Ministry of Education, Beijing 100029;
出版信息
Biomed Rep. 2013 May;1(3):341-346. doi: 10.3892/br.2013.67. Epub 2013 Feb 25.
Dysglycemia (hyper- and hypoglycemia) has been associated with higher mortality among patients suffering from myocardial infarction (MI). Moreover, dysglycemia may induce cell death. Cell death (necrosis, apoptosis and autophagy) is a ubiquitous process that characterizes the course of several diseases, including MI, and occurs in diverse forms varying in mechanism, pattern and consequence. Therefore, cell death is a potential pathway through which dysglycemia affects the outcome of MI and it is essential to regulate myocardial cell death in the treatment of patients with MI caused by dysglycemia. In this review, we summarized the mechanisms of MI at the cellular level and the regulatory effects of dysglycemia on myocardial cell death. The ability to modulate myocardial cell death may be a promising target of new treatments aimed at limiting MI caused by dysglycemia. However, further research is required to elucidate the mechanisms underlying cell death regulation in MI caused by dysglycemia.
血糖异常（高血糖和低血糖）与心肌梗死（MI）患者的较高死亡率相关。此外，血糖异常可能诱导细胞死亡。细胞死亡（坏死、凋亡和自噬）是一个普遍存在的过程，它是包括MI在内的多种疾病病程的特征，并且以机制、模式和后果各不相同的多种形式发生。因此，细胞死亡是血糖异常影响MI结局的一条潜在途径，在治疗由血糖异常引起的MI患者时调节心肌细胞死亡至关重要。在本综述中，我们总结了细胞水平上MI的机制以及血糖异常对心肌细胞死亡的调节作用。调节心肌细胞死亡的能力可能是旨在限制由血糖异常引起的MI的新治疗方法的一个有前景的靶点。然而，需要进一步研究以阐明由血糖异常引起的MI中细胞死亡调节的潜在机制。
Zotero 插件