Yang Yi, Gu Xiaodong, Zhou Minwei, Xiang Jianbin, Chen Zongyou
Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
Biomed Rep. 2013 Jul;1(4):495-498. doi: 10.3892/br.2013.109. Epub 2013 May 20.
Colorectal cancer (CRC) is the third most common malignant tumor worldwide, affecting over 1.23 million individuals annually. Over the past several years, the role of microRNAs (miRNAs) in CRC cells have been extensively investigated. Recently, it was discovered that extracellular miRNAs circulate in the blood of healthy individuals as well as CRC patients. Serum circulating miRNAs as novel biomarkers may be a new approach to CRC diagnosis. However, their secretory mechanism and biological function have not been fully elucidated. In this review, the main serum miRNAs used as potential diagnostic biomarkers for CRC, such as miR-92, miR-141, miR-29a, miR-21, miR-221, miR-601 and miR-760, were summarized. In addition, the mechanism of miRNA secretion from CRC cells was discussed. It is recommended that additional studies focus on the usefulness of serum miRNAs for early CRC diagnosis, prognosis and therapeutics.
结直肠癌（CRC）是全球第三大常见恶性肿瘤，每年影响超过123万人。在过去几年中，微小RNA（miRNA）在CRC细胞中的作用已得到广泛研究。最近，人们发现细胞外miRNA在健康个体以及CRC患者的血液中循环。血清循环miRNA作为新型生物标志物可能是CRC诊断的一种新方法。然而，它们的分泌机制和生物学功能尚未完全阐明。在本综述中，总结了用作CRC潜在诊断生物标志物的主要血清miRNA，如miR-92、miR-141、miR-29a、miR-21、miR-221、miR-601和miR-760。此外，还讨论了CRC细胞中miRNA的分泌机制。建议进一步研究关注血清miRNA在CRC早期诊断、预后和治疗中的作用。
