Nozoe Tadahiro, Iguchi Tomohiro, Maeda Takashi, Kohno Mayuko, Ezaki Takahiro
Department of Surgery, Fukuoka Higashi Medical Center, Koga 811-3195, Japan.
Mol Clin Oncol. 2013 Jan;1(1):171-174. doi: 10.3892/mco.2012.32. Epub 2012 Oct 2.
The aim of the present study was to establish a series of criteria based on lymphopenia and thrombocytosis to determine prognosis for patients with colorectal carcinoma. Correlation of preoperative lymphopenia and thrombocytosis with clinicopathological characteristics was investigated in 215 patients with colorectal carcinoma who had undergone surgical treatment. Multivariate analysis showed that the presence of at least either lymphopenia or thrombocytosis (P=0.006), venous invasion (P=0.003) and the stage of tumors (P=0.019) were independent prognostic indicators. Lymphocyte percentage and platelet counts that can be determined using only data from complete blood counts may therefore serve as simple and useful tools to appropriately determine prognosis for patients with colorectal carcinoma.
本研究的目的是基于淋巴细胞减少症和血小板增多症建立一系列标准，以确定结直肠癌患者的预后。在215例接受手术治疗的结直肠癌患者中，研究术前淋巴细胞减少症和血小板增多症与临床病理特征的相关性。多因素分析显示，至少存在淋巴细胞减少症或血小板增多症（P = 0.006）、静脉侵犯（P = 0.003）和肿瘤分期（P = 0.019）是独立的预后指标。因此，仅使用全血细胞计数数据即可确定的淋巴细胞百分比和血小板计数，可作为简单而有用的工具，用于合理确定结直肠癌患者的预后。
