Zhang Hong-Bo, Lu Ping, Cao Wen-Bo, Zhang Zhen-Hua, Meng Xiang-Lei
Department of Anatomy and Cell Biology, School of Medicine, Zhengzhou University, Zhengzhou, Henan 450001; ; Department of Cancer Biology, School of Medicine, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan 450008;
Mol Clin Oncol. 2013 Mar;1(2):395-399. doi: 10.3892/mco.2012.52. Epub 2012 Dec 17.
Chinese herbs are potential sources of antitumor drugs with immunoregulatory activity and few adverse effects. In the present study, we investigated whether the Thunb. (HJT) extract enhanced the efficacy of 5-fluorouracil (5-FU) treatment in murine liver tumor xenografts and reduced toxicity of chemotherapy in hepatoma H22-bearing mice. Tumor weight and inhibition rate, thymus and spleen indices, as well as white blood cell (WBC) count were calculated. The phagocytic function of macrophages was assessed by observing peritoneal macrophages phagocytized chicken red blood cells (RBC). Body weight and toxic reactions of the chemotherapeutic and life prolongation rate were investigated in the mice. Results demonstrated that the HJT extract significantly enhanced the tumor inhibition rate of 5-FU, improved the immune function, reduced the toxic effects and prolonged the survival time in the tumor-bearing mice. Taken together, these results indicated that the HJT extract has a synergistic tumor-inhibiting effect with 5-FU, is able to reduce the toxic side effects and is likely to be safe and efficacious for use in antitumor therapy.
中草药是具有免疫调节活性且副作用少的潜在抗肿瘤药物来源。在本研究中，我们调查了水飞蓟提取物（HJT）是否能增强5-氟尿嘧啶（5-FU）对小鼠肝肿瘤异种移植的治疗效果，并降低荷肝癌H22小鼠化疗的毒性。计算肿瘤重量和抑制率、胸腺和脾脏指数以及白细胞（WBC）计数。通过观察腹腔巨噬细胞吞噬鸡红细胞（RBC）来评估巨噬细胞的吞噬功能。研究了小鼠的体重、化疗的毒性反应和生命延长率。结果表明，HJT提取物显著提高了5-FU的肿瘤抑制率，改善了免疫功能，降低了毒性作用，并延长了荷瘤小鼠的生存时间。综上所述，这些结果表明HJT提取物与5-FU具有协同抑瘤作用，能够减少毒副作用，可能安全有效地用于抗肿瘤治疗。
