一种来自地耳草的新的间苯三酚二糖苷衍生物。
A new phloroglucinol diglycoside derivative from Hypericum japonicum Thunb.
作者信息
Wang Xiao Wei, Mao Yu, Wang Nai-Li, Yao Xin Sheng
机构信息
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang, Liaoning, PR China.
出版信息
Molecules. 2008 Nov 7;13(11):2796-803. doi: 10.3390/molecules13112796.
A new phloroglucinol diglycoside 1, together with eight known compounds, were isolated from Hypericum japonicum Thunb. The structure of the new compound 1 was determined by spectroscopic methods to be 4,6-dimethyl-5-O-[alpha-L-rhamnopyranosyl-(1-->6)-alpha-D-glucopyranosyl] multifidol. Different solvent extracts of Hypericum japonicum Thunb. were tested for in vivo antihypoxic activity using mice, with the EtOAc extract showing better activity.
从地耳草中分离得到一个新的间苯三酚二糖苷1以及八个已知化合物。通过光谱方法确定新化合物1的结构为4,6-二甲基-5-O-[α-L-鼠李糖基-(1→6)-α-D-葡萄糖基]金丝桃醇。用地耳草的不同溶剂提取物对小鼠进行体内抗缺氧活性测试，结果表明乙酸乙酯提取物具有更好的活性。
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