Yuan Na, Meng Min, Liu Caigang, Feng Lu, Hou Lei, Ning Qian, Xin Guohong, Pei Li, Gu Shanzhi, Li Xiao, Zhao Xinhan
Department of Oncology, First Affiliated Hospital of Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
Department of Breast Surgery, Research Unit of General Surgery, First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Mol Clin Oncol. 2014 Mar;2(2):245-251. doi: 10.3892/mco.2013.230. Epub 2013 Dec 20.
It is well-established that triple-negative breast cancer (TNBC) is a subtype of breast cancer, characterized by a poor prognosis and aggressive biological behavior. However, the available relevant data on TNBC in non-Western populations are limited. In order to analyze the clinicopathological and molecular biological characteristics and observe survival and prognostic factors, 972 breast cancer patients (156 of whom had TNBC) who received treatment at the First Affiliated Hospital of Medical School of Xi'an Jiaotong University and the First Hospital of China Medical University, between January, 2004 and January, 2007 were retrospectively evaluated. In the univariate analysis, tumor size, TNM stage, axillary lymph node status and recurrence or metastasis were identified as prognostic factors for 7-year disease-free survival (DFS) and overall survival (OS). Our multivariate Cox's regression analysis demonstrated that tumor size and axillary lymph node status were significant prognostic factors for 7-year DFS and OS. Notably, tumor subgroup (TNBC vs. non-TNBC) was a significant prognostic factor associated with 7-year DFS and OS in breast cancer. It was suggested that TNBC exhibited a worse 7-year survival compared with that in non-TNBC patients, most likely due to its more aggressive behavior and insensitivity to specific therapy.
三阴性乳腺癌（TNBC）是乳腺癌的一种亚型，其预后较差且具有侵袭性生物学行为，这一点已得到充分证实。然而，非西方人群中关于TNBC的现有相关数据有限。为了分析临床病理和分子生物学特征并观察生存及预后因素，对2004年1月至2007年1月期间在西安交通大学医学院第一附属医院和中国医科大学第一医院接受治疗的972例乳腺癌患者（其中156例为TNBC）进行了回顾性评估。单因素分析中，肿瘤大小、TNM分期、腋窝淋巴结状态以及复发或转移被确定为7年无病生存（DFS）和总生存（OS）的预后因素。多因素Cox回归分析表明，肿瘤大小和腋窝淋巴结状态是7年DFS和OS的显著预后因素。值得注意的是，肿瘤亚组（TNBC与非TNBC）是与乳腺癌7年DFS和OS相关的显著预后因素。提示TNBC患者7年生存率较非TNBC患者差，这很可能是由于其行为更具侵袭性且对特定治疗不敏感。
