Ishino H, Higashi S, Chûta M, Ohta H
Clin Neuropathol. 1984 Sep-Oct;3(5):193-8.
A case of juvenile Alzheimer's disease is reported with onset at 34 years of age, a clinical course of 6 years, had myoclonic jerks, generalized convulsions, dysarthria and ataxic symptoms. The neuropathological examination indicated kuru-plaques, amyloid angiopathy and grumose alteration (degeneration) in the dentate nucleus. In this case, the plaques in Alzheimer disease is quite rare. This case also demonstrates the complex interrelationship between Alzheimer's disease and various multisystemic degeneration mainly involving the dentate nucleus.
报告了一例34岁起病的青少年型阿尔茨海默病病例，临床病程为6年，有肌阵挛性抽搐、全身性惊厥、构音障碍和共济失调症状。神经病理学检查显示有库鲁斑、淀粉样血管病以及齿状核的颗粒样改变（变性）。在该病例中，阿尔茨海默病中的斑块相当罕见。此病例还证明了阿尔茨海默病与主要累及齿状核的各种多系统变性之间复杂的相互关系。
