Scopsi L, Balslev E, Brünner N, Poulsen H S, Andersen J, Rank F, Larsson L I
Unit of Histochemistry, University of Copenhagen, Denmark.
Am J Pathol. 1989 Feb;134(2):473-9.
Opioid peptides have a variety of actions on inter alia pituitary hormone secretion and the immune system. Release of endogenous opioids has been found to stimulate growth of experimental breast cancers and opiate receptor blockers have reduced the growth of chemically induced rat breast tumors. Opioid peptides may therefore play a role in human breast cancer. Invasive ductal carcinomas from 61 premenopausal women were immunocytochemically analyzed for the presence of opioid peptide immunoreactivity. Positive staining was unambiguously identified in 34 of the tumors (56%). In addition, a medullary carcinoma was positive. In a smaller series of tumors, opioid peptide immunoreactive cells were detected in both primary tumors and metastases. Positive tumor cells were usually few and scattered. Therefore, underestimates of their true frequency of occurrence are likely to have occurred, making accurate correlations with clinical behavior and estrogen receptor status difficult. No correlations with estrogen receptors were established for the unambiguously opioid peptide-positive tumors. Many of the positive tumors also stained with antibodies to gamma-endorphin and alpha-melanocyte-stimulating hormone, suggesting the presence of proopiomelanocortin-derived peptides in them. However, peptides derived from other opioid precursors also may be present in breast cancer.
阿片肽对垂体激素分泌以及免疫系统等具有多种作用。已发现内源性阿片类物质的释放会刺激实验性乳腺癌的生长，而阿片受体阻滞剂则可抑制化学诱导的大鼠乳腺肿瘤的生长。因此，阿片肽可能在人类乳腺癌中发挥作用。对61名绝经前女性的浸润性导管癌进行免疫细胞化学分析，以检测阿片肽免疫反应性的存在。在34个肿瘤（56%）中明确鉴定出阳性染色。此外，有一例髓样癌呈阳性。在较少的一系列肿瘤中，在原发性肿瘤和转移灶中均检测到阿片肽免疫反应性细胞。阳性肿瘤细胞通常很少且分散。因此，可能低估了它们实际出现的频率，使得难以与临床行为和雌激素受体状态进行准确关联。对于明确为阿片肽阳性的肿瘤，未建立与雌激素受体的相关性。许多阳性肿瘤也用γ-内啡肽和α-黑素细胞刺激素抗体染色，表明其中存在阿片-促黑素细胞皮质素原衍生的肽。然而，源自其他阿片前体的肽也可能存在于乳腺癌中。
