Domagala W, Harezga B, Szadowska A, Markiewski M, Weber K, Osborn M
Department of Tumor Pathology, Medical Academy, Szczecin, Poland.
Am J Pathol. 1993 Mar;142(3):669-74.
Striking differences were found between different histological types of breast cancer when 263 invasive breast carcinomas were tested for nuclear p53 accumulation in formaldehyde-fixed paraffin sections. Nuclear p53 accumulation was found in > 10% of tumor cells in 61% of medullary carcinomas (22/36), 37% of grade 3 ductal not otherwise specified carcinomas (32/86), 4% of lobular carcinomas (2/47), and 0% (0/7) of mucinous carcinomas. Strong cytoplasmic p53 staining was noted in 32% of lobular carcinomas. High percentages of medullary and high-grade ductal breast carcinomas accumulate nuclear p53, but these tumors have favorable and poor prognoses, respectively. Thus, whereas nuclear p53 accumulation can be associated in these tumors with high morphological malignancy grades in general and with tumor cell proliferation in particular, p53 accumulation is not necessarily correlated with biological aggressiveness. Overall incidence of p53-positive tumors in a particular series of breast carcinomas (in our study 28%) will depend on the ratio of ductal not otherwise specified, medullary, and lobular carcinomas.
在对263例浸润性乳腺癌的甲醛固定石蜡切片进行核p53积聚检测时，发现不同组织学类型的乳腺癌之间存在显著差异。在61%的髓样癌（22/36）、37%的未另行规定的3级导管癌（32/86）、4%的小叶癌（2/47）和0%的黏液癌（0/7）中，发现>10%的肿瘤细胞存在核p53积聚。在32%的小叶癌中观察到强细胞质p53染色。髓样癌和高级别导管癌中核p53积聚的比例较高，但这些肿瘤的预后分别较好和较差。因此，虽然在这些肿瘤中，核p53积聚一般与高形态学恶性程度相关，特别是与肿瘤细胞增殖相关，但p53积聚不一定与生物学侵袭性相关。特定系列乳腺癌中p53阳性肿瘤的总体发生率（在我们的研究中为28%）将取决于未另行规定的导管癌、髓样癌和小叶癌的比例。
