Wong K S, Giam Y C
Middle Road Hospital, Singapore.
Ann Acad Med Singap. 1988 Oct;17(4):524-5.
From January 1985 to January 1986, a group of patients suffering from verruca vulgaris were treated with intralesional bleomycin in Middle Road Hospital. Each skin lesion was injected with 0.1% solution of bleomycin solution, up to a maximum of three injections per lesion. Patients were reviewed fortnightly for 6 weeks. Out of 35 patients who completed the study, 29 patients (83%) were initially cleared of their warts, and 3 patients had partial clearance. 3 patients had recurrence of lesions on follow-up. An average of 1.5 treatment sessions was required for each patient. Scarring and pigmentary changes at injection sites were minimal. No systemic side effects were observed. This study shows that intralesional bleomycin is a safe and effective method for treating viral warts.
1985年1月至1986年1月，中路医院使用博来霉素皮损内注射治疗了一组寻常疣患者。每个皮损注射0.1%的博来霉素溶液，每个皮损最多注射3次。患者每两周复查一次，共复查6周。在完成研究的35例患者中，29例（83%）患者的疣体最初清除，3例部分清除。3例患者在随访中出现皮损复发。每位患者平均需要1.5次治疗。注射部位的瘢痕形成和色素沉着变化极小。未观察到全身副作用。本研究表明，博来霉素皮损内注射是治疗病毒性疣的一种安全有效的方法。
