Department of Dermatology, Venereology and Leprosy, Dr. R. P. Government Medical College, Kangra, Himachal Pradesh, India.
Indian J Dermatol Venereol Leprol. 2019 Jul-Aug;85(4):397-404. doi: 10.4103/ijdvl.IJDVL_519_17.
This study evaluated the efficacy and safety of intralesional bleomycin in the treatment of common warts in 50 (32 men, 18 women) patients aged between 14 and 80 (mean ± SD, 28.5 ± 13.27) years.
The warts were present over dorsal hands, feet, palms, soles and periungual skin for 1 month to 10 years. They were infiltrated with bleomycin (1 mg/ml) till blanching. The total cumulative dose did not exceed 2 mg in one session. The treatment was repeated after paring of eschar at 2 weeks in case there was no or partial response. The patients were reviewed at 4, 12 and 24 weeks for cure, adverse effects or recurrences and outcome satisfaction levels.
Complete cure without recurrence occurred in 40 (80%) patients and partial response occurred in 7 (14%) patients at the end of the 24-week study period. Three patients did not complete follow-up. No major systemic or local adverse effects other than injection site pain for 2-3 days were noted. All cured patients were very satisfied (Likert scale 5).
Intralesional bleomycin appears to be an effective and safe treatment for common warts including palmoplantar and periungual warts. It carries the advantage of low dose, no significant adverse effects and high patient satisfaction. Small number of patients, lack of a control group, comparing different bleomycin concentrations and a short follow-up are a few limitations of this study. Better designed studies are warranted for this useful treatment modality.
本研究评估了局内注射平阳霉素治疗 50 例（32 男，18 女）年龄在 14 至 80 岁（均数±标准差，28.5±13.27）岁的寻常疣患者的疗效和安全性。
这些疣位于手部背侧、足部、手掌、足底和甲周皮肤，病程 1 个月至 10 年。用平阳霉素（1mg/ml）行浸润注射，直至变白。每次治疗的总累积剂量不超过 2mg。如果没有完全缓解或部分缓解，在 2 周内行焦痂刮除后重复治疗。在第 4、12 和 24 周时评估患者的治愈情况、不良反应或复发情况以及对结局的满意度。
在 24 周的研究结束时，40 例（80%）患者完全治愈且无复发，7 例（14%）患者部分缓解。3 例患者未完成随访。除注射部位疼痛 2-3 天外，未观察到其他重大全身或局部不良反应。所有治愈患者均非常满意（Likert 量表 5 级）。
平阳霉素局内注射似乎是一种治疗寻常疣，包括掌跖部和甲周疣的有效且安全的方法。其具有低剂量、无明显不良反应和高患者满意度的优点。本研究存在一些局限性，如患者数量较少、缺乏对照组、不同平阳霉素浓度的比较以及随访时间较短。需要更好设计的研究来验证这种有用的治疗方法。
