Rižner Tea Lanišnik
Expert Rev Mol Diagn. 2014 Apr;14(3):365-85. doi: 10.1586/14737159.2014.899905.
Endometriosis affects 10% of premenopausal women and 35-50% of women with infertility, pelvic pain, or both. At present, endometriosis can only be diagnosed with surgery, where laparoscopy is considered a gold standard. Noninvasive biomarkers are thus urgently needed. In 2010, the peripheral biomarkers of endometriosis were systematically reviewed by May et al. However, with the introduction of '-omics' technologies, we have witnessed immense progress in biomarker discovery, which now calls for an overview of recent studies. This report looks at potential blood and urine biomarkers of endometriosis published in the last 3 years. The current status of noninvasive diagnostic biomarkers of endometriosis is discussed, with the limitations of these studies identified and recommendations for future biomarker discovery provided.
子宫内膜异位症影响10%的绝经前女性以及35%-50%患有不孕症、盆腔疼痛或两者皆有的女性。目前，子宫内膜异位症只能通过手术诊断，其中腹腔镜检查被视为金标准。因此，迫切需要非侵入性生物标志物。2010年，梅等人对子宫内膜异位症的外周生物标志物进行了系统综述。然而，随着“组学”技术的引入，我们见证了生物标志物发现方面的巨大进展，现在需要对近期研究进行概述。本报告审视了过去3年发表的子宫内膜异位症潜在血液和尿液生物标志物。讨论了子宫内膜异位症非侵入性诊断生物标志物的现状，指出了这些研究的局限性，并为未来生物标志物的发现提供了建议。
