Mazzoccoli Gianluigi, Vinciguerra Manlio, Oben Jude, Tarquini Roberto, De Cosmo Salvatore
Division of Internal Medicine and Chronobiology Unit, Department of Medical Sciences, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo (FG), Italy.
Liver Int. 2014 Sep;34(8):1133-52. doi: 10.1111/liv.12534. Epub 2014 Apr 9.
Non-alcoholic fatty liver disease (NAFLD) is the accumulation of triglycerides in the hepatocytes in the absence of excess alcohol intake, and is caused by an imbalance between hepatic synthesis and breakdown of fats, as well as fatty acid storage and disposal. Liver metabolic pathways are driven by circadian biological clocks, and hepatic health is maintained by proper timing of circadian patterns of metabolic gene expression with the alternation of anabolic processes corresponding to feeding/activity during wake times, and catabolic processes characterizing fasting/resting during sleep. A number of nuclear receptors in the liver are expressed rhythmically, bind hormones and metabolites, sense energy flux and expenditure, and connect the metabolic pathways to the molecular clockwork throughout the 24-h day. In this review, we describe the role played by the nuclear receptors in the genesis of NAFLD in relationship with the circadian clock circuitry.
非酒精性脂肪性肝病（NAFLD）是指在无过量酒精摄入的情况下，肝细胞内甘油三酯的蓄积，其由肝脏脂肪合成与分解、脂肪酸储存与代谢之间的失衡所引起。肝脏代谢途径受昼夜生物钟驱动，通过代谢基因表达的昼夜节律模式与清醒时进食/活动所对应的合成代谢过程以及睡眠时禁食/休息所特有的分解代谢过程的适时交替来维持肝脏健康。肝脏中的一些核受体呈节律性表达，它们结合激素和代谢产物，感知能量通量和消耗，并在全天24小时内将代谢途径与分子时钟机制相联系。在本综述中，我们描述了核受体在与昼夜节律时钟电路相关的NAFLD发生过程中所起的作用。
