胆囊切除术作为代谢功能障碍相关脂肪性肝病的危险因素：揭示胆汁酸肠肝循环背后的代谢和生物钟线索

Cholecystectomy as a risk factor for metabolic dysfunction-associated fatty liver disease: unveiling the metabolic and chronobiologic clues behind the bile acid enterohepatic circulation.

作者信息

Qi Li, Dai Wanlin, Kong Jing, Tian Yu, Chen Yongsheng

机构信息

Department of Rheumatology and Immunology, Shengjing Hospital of China Medical University, No. 39, Hua xiang Road, Tiexi District, Shenyang, 110022, Liaoning Province, China.

Innovation Institute of China Medical University, No. 77, Pu He Road, Shenbeixin District, Shenyang, 110004, Liaoning Province, China.

出版信息

J Physiol Biochem. 2021 Nov;77(4):497-510. doi: 10.1007/s13105-020-00782-w. Epub 2021 Jul 24.

DOI:10.1007/s13105-020-00782-w

PMID:34302623

Abstract

Metabolic dysfunction-associated fatty liver disease (MAFLD) is highly prevalent worldwide. Recent clinical and experimental studies have addressed the association between cholecystectomy and MAFLD, confirming that cholecystectomy is an independent risk factor for MAFLD. In this review, we describe the epidemiologic evidence that links cholecystectomy to MAFLD, and discuss the possible mechanisms behind these connections, in order to unveil the metabolic and chronobiologic signals conveyed by the waves of the bile acid enterohepatic circulation.

摘要

代谢功能障碍相关脂肪性肝病（MAFLD）在全球范围内高度流行。最近的临床和实验研究探讨了胆囊切除术与MAFLD之间的关联，证实胆囊切除术是MAFLD的一个独立危险因素。在本综述中，我们描述了将胆囊切除术与MAFLD联系起来的流行病学证据，并讨论了这些关联背后的可能机制，以便揭示胆汁酸肠肝循环波动所传递的代谢和生物钟信号。