早年生活逆境与中年成年人循环中瘦素、鸢尾素水平升高以及脂联素水平降低有关。
Early life adversity is associated with elevated levels of circulating leptin, irisin, and decreased levels of adiponectin in midlife adults.
作者信息
Joung Kyoung Eun, Park Kyung-Hee, Zaichenko Lesya, Sahin-Efe Ayse, Thakkar Bindiya, Brinkoetter Mary, Usher Nicole, Warner Dorothy, Davis Cynthia R, Crowell Judith A, Mantzoros Christos S
机构信息
Division of Newborn Medicine (K.E.J.), Boston Children's Hospital, Boston, Division of Endocrinology and Metabolism (K.E.J., K.-H.P., L.Z., A.S.-E., B.T., M.B., C.S.M.), Beth Israel Deaconess Medical Center, and Harvard Medical School (K.E.J., C.S.M.), Boston, Massachusetts 02215; Department of Family Medicine (K.-H.P.), Hallym University Sacred Heart Hospital, Hallym University, Gyeonggi-do 431-070, Korea; Section of Endocrinology (L.Z., A.S.-E., B.T., M.B., C.S.M.), Division of Endocrinology, Boston Veterans Affairs Healthcare System, Jamaica Plain, Massachusetts 02130; Section of Endocrinology, Diabetes, and Nutrition (A.S.-E., B.T., C.S.M.), Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118; Judge Baker Children's Center (N.U., D.W., C.R.D., J.A.C.), Boston, Massachusetts 02120; and Department of Psychiatry and Behavioral Sciences (J.A.C.), Stony Brook University School of Medicine, Stony Brook, New York 11794.
出版信息
J Clin Endocrinol Metab. 2014 Jun;99(6):E1055-60. doi: 10.1210/jc.2013-3669. Epub 2014 Mar 20.
CONTEXT
Early-life adversity, defined as physical, emotional, or sexual abuse and neglect before 18 years of age, is associated with metabolic syndrome, obesity, and type 2 diabetes mellitus in adult life. However, the underlying mechanism is not fully understood, and whether adipomyokines are associated with early-life adversity independent of other factors such as body mass index, psychosocial risks, and health behaviors is not known.
OBJECTIVES
The objective of the study was to evaluate the association between early-life adversity and circulating the levels of the adipomyokines such as leptin, adiponectin, and irisin and the inflammatory marker, C-reactive protein (CRP). DESIGN/SUBJECTS/SETTING: This study was a cross-sectional study of 95 adults at a university-based research center. We collected venous blood from participants and analyzed serum for leptin, adiponectin, irisin, and CRP.
RESULTS
Circulating leptin, irisin, and CRP levels were significantly higher in the highest adversity tertile group compared with low and middle tertile groups (P < .001 for leptin, P = .01 for irisin, and P = .02 for CRP). Adiponectin levels were lower in the highest tertile group compared with the low and middle tertile groups (P = .03). After adjusting for demographic variables, physical activity, diet, current mental health, and body mass index, the associations between early-life adversity leptin, irisin, and did not change. However, adiponectin and CRP levels were no longer significantly related to early life adversity.
CONCLUSION
Early-life adversity is directly associated with elevated circulating leptin and irisin, and indirectly associated with elevated CRP and decreased adiponectin. These findings suggest that these adipomyokines may play a role in the pathogenesis of metabolic abnormality in a population with significant early life adversity.
背景
早年逆境被定义为18岁之前遭受的身体、情感或性虐待及忽视，与成年后的代谢综合征、肥胖症和2型糖尿病有关。然而，其潜在机制尚未完全明确，且脂联素是否独立于其他因素（如体重指数、心理社会风险和健康行为）与早年逆境相关尚不清楚。
目的
本研究的目的是评估早年逆境与循环中瘦素、脂联素、鸢尾素等脂肪因子水平以及炎症标志物C反应蛋白（CRP）之间的关联。
设计/研究对象/研究地点：本研究是在一所大学研究中心对95名成年人进行的横断面研究。我们采集了参与者的静脉血，并分析血清中的瘦素、脂联素、鸢尾素和CRP。
结果
与低逆境三分位数组和中逆境三分位数组相比，高逆境三分位数组的循环瘦素、鸢尾素和CRP水平显著更高（瘦素P <.001，鸢尾素P =.01，CRP P =.02）。与低逆境三分位数组和中逆境三分位数组相比，高逆境三分位数组的脂联素水平较低（P =.03）。在调整了人口统计学变量、身体活动、饮食、当前心理健康状况和体重指数后，早年逆境与瘦素、鸢尾素之间的关联没有改变。然而，脂联素和CRP水平与早年逆境不再显著相关。
结论
早年逆境与循环中瘦素和鸢尾素升高直接相关，与CRP升高和脂联素降低间接相关。这些发现表明，这些脂肪因子可能在有显著早年逆境的人群代谢异常的发病机制中起作用。
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