Ports Katie A, Holman Dawn M, Guinn Angie S, Pampati Sanjana, Dyer Karen E, Merrick Melissa T, Lunsford Natasha Buchanan, Metzler Marilyn
Division of Violence Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.
J Pediatr Nurs. 2019 Jan-Feb;44:81-96. doi: 10.1016/j.pedn.2018.10.009. Epub 2018 Nov 7.
Exposure to Adverse Childhood Experiences (ACEs) is associated with a host of harmful outcomes, including increased risk for cancer. A scoping review was conducted to gain a better understanding of how ACEs have been studied in association with risk factors for cancer. This review includes 155 quantitative, peer-reviewed articles published between 2005 and 2015 that examined associations between ACEs and modifiable cancer risk factors, including alcohol, environmental carcinogens, chronic inflammation, sex hormones, immunosuppression, infectious agents, obesity, radiation, ultraviolet (UV) radiation, and tobacco, among U.S. adults. This review highlights the growing body of research connecting ACEs to cancer risk factors, particularly alcohol, obesity, and tobacco. Fewer studies investigated the links between ACEs and chronic inflammation or infectious agents. No included publications investigated associations between ACEs and environmental carcinogens, hormones, immunosuppression, radiation, or ultraviolet radiation. Mitigating the impact of ACEs may provide innovative ways to effect comprehensive, upstream cancer prevention.
童年不良经历（ACEs）与一系列有害后果相关，包括患癌风险增加。开展了一项范围综述，以更好地了解ACEs与癌症风险因素之间的研究情况。该综述纳入了2005年至2015年间发表的155篇经过同行评审的定量研究文章，这些文章探讨了美国成年人中ACEs与可改变的癌症风险因素之间的关联，这些风险因素包括酒精、环境致癌物、慢性炎症、性激素、免疫抑制、感染因子、肥胖、辐射、紫外线（UV）辐射和烟草。该综述强调了将ACEs与癌症风险因素联系起来的研究日益增多，尤其是酒精、肥胖和烟草。较少有研究调查ACEs与慢性炎症或感染因子之间的联系。纳入的出版物中没有研究ACEs与环境致癌物、激素、免疫抑制、辐射或紫外线辐射之间的关联。减轻ACEs的影响可能为实现全面的上游癌症预防提供创新方法。
