Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Department of Family Medicine, Hallym University Sacred Heart Hospital, Hallym University, Gyeonggi-do, 431-796, Korea.
Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Metabolism. 2014 Feb;63(2):233-41. doi: 10.1016/j.metabol.2013.10.011. Epub 2013 Oct 29.
Adherence to a healthy diet has been shown to decrease the incidence of obesity and associated comorbidities. C-reactive protein (CRP) is an established inflammatory marker and irisin was recently identified as a molecule which may play a role in energy regulation and obesity but whether diet alters irisin levels remains unknown. We aimed to investigate the association between circulating irisin, leptin, and CRP levels and dietary quantity and quality using the Alternate Healthy Eating Index (AHEI) and the Alternate Mediterranean Diet Score (aMED).
MATERIALS/METHODS: The study evaluated dietary data and biomarker levels of 151 participants between 2009 and 2011 (71 male vs. 80 female, over 35 years old, obese 43.7%). AHEI and aMED scores were calculated based on data derived from self-administered 110-item food-frequency questionnaires estimating usual nutrient intake over the past year. Cross-sectional associations between dietary quantity, quality, body composition by bioelectric impedance, and biomarker levels including irisin, leptin, and CRP after fasting were assessed.
CRP, but not irisin, was negatively correlated with AHEI (r=-0.34) and aMED (r=-0.31). Irisin was positively correlated with BMI (r=0.22), fat mass (r=0.21), waist circumference (r=0.24), waist-hip ratio (r=0.20), leptin (r=0.32), and CRP (r=0.25). Participants with the highest AHEI scores tended to have 11.6% lower concentrations of irisin (P for trend =0.09), but they were not significant after adjustment for potential confounders. Better diet quality was associated with lower CRP concentrations (P for trend=0.02) in multivariate model. Percentage of energy from carbohydrate was inversely associated with CRP.
Unlike CRP, irisin is not associated with dietary quality or quantity.
已证实，坚持健康饮食可降低肥胖症及相关并发症的发生率。C 反应蛋白（CRP）是一种已确立的炎症标志物，而鸢尾素最近被确定为一种可能在能量调节和肥胖中发挥作用的分子，但饮食是否会改变鸢尾素水平尚不清楚。我们旨在使用交替健康饮食指数（AHEI）和交替地中海饮食评分（aMED）来研究循环鸢尾素、瘦素和 CRP 水平与饮食数量和质量之间的关系。
材料/方法：该研究评估了 2009 年至 2011 年期间 151 名参与者的饮食数据和生物标志物水平（71 名男性与 80 名女性，年龄超过 35 岁，肥胖者占 43.7%）。根据来自自我管理的 110 项食物频率问卷的数据计算 AHEI 和 aMED 评分，该问卷估计过去一年的常用营养素摄入量。评估空腹后饮食数量、质量、生物电阻抗法测定的身体成分与包括鸢尾素、瘦素和 CRP 在内的生物标志物水平之间的横断面关联。
CRP 而非鸢尾素与 AHEI（r=-0.34）和 aMED（r=-0.31）呈负相关。鸢尾素与 BMI（r=0.22）、脂肪量（r=0.21）、腰围（r=0.24）、腰臀比（r=0.20）、瘦素（r=0.32）和 CRP（r=0.25）呈正相关。AHEI 得分最高的参与者的鸢尾素浓度往往低 11.6%（趋势 P=0.09），但在调整潜在混杂因素后无统计学意义。更好的饮食质量与 CRP 浓度较低相关（趋势 P=0.02），在多变量模型中。碳水化合物能量百分比与 CRP 呈负相关。
与 CRP 不同，鸢尾素与饮食质量或数量无关。
