抗叶酸聚谷氨酸对人二氢叶酸还原酶的抑制作用。 - Suppr | 超能文献

Inhibition of human dihydrofolate reductase by antifolyl polyglutamates.

作者信息

Kumar P, Kisliuk R L, Gaumont Y, Freisheim J H, Nair M G

机构信息

Department of Biochemistry, Tufts University, Health Science Campus, Boston, MA 02111.

出版信息

Biochem Pharmacol. 1989 Feb 1;38(3):541-3. doi: 10.1016/0006-2952(89)90397-3.

DOI:10.1016/0006-2952(89)90397-3

Abstract

摘要

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。

相似文献

1

Inhibition of human dihydrofolate reductase by antifolyl polyglutamates.抗叶酸聚谷氨酸对人二氢叶酸还原酶的抑制作用。

Biochem Pharmacol. 1989 Feb 1;38(3):541-3. doi: 10.1016/0006-2952(89)90397-3.

2

Interaction of polyglutamyl derivatives of methotrexate, 10-deazaaminopterin, and dihydrofolate with dihydrofolate reductase.甲氨蝶呤、10-脱氮氨基蝶呤和二氢叶酸的聚谷氨酰衍生物与二氢叶酸还原酶的相互作用。

Cancer Res. 1986 Oct;46(10):5020-3.

3

Mechanisms of sensitivity and natural resistance to antifolates in a methylcholanthrene-induced rat sarcoma.甲基胆蒽诱导的大鼠肉瘤中对抗叶酸剂敏感性和天然抗性的机制。

Mol Pharmacol. 1991 Nov;40(5):854-8.

4

Synthesis and biological evaluation of poly-gamma-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin.10-脱氮氨基蝶呤和10-乙基-10-脱氮氨基蝶呤的聚γ-谷氨酰代谢产物的合成及生物学评价

J Med Chem. 1988 Jan;31(1):181-5. doi: 10.1021/jm00396a029.

5

Predictions of a network thermodynamics computer model relating to the mechanism of methotrexate rescue by 5-formyltetrahydrofolate and to the importance of inhibition of thymidylate synthase by methotrexate-polyglutamates.一个网络热力学计算机模型的预测，该模型涉及5-甲酰四氢叶酸对甲氨蝶呤的解救机制以及甲氨蝶呤多聚谷氨酸对胸苷酸合成酶抑制作用的重要性。

Adv Exp Med Biol. 1983;163:305-26. doi: 10.1007/978-1-4757-5241-0_23.

6

Cytotoxicity, uptake, polyglutamate formation, and antileukemic effects of 8-deaza analogues of methotrexate and aminopterin in mice.甲氨蝶呤和氨基蝶呤的8-脱氮类似物在小鼠体内的细胞毒性、摄取、聚谷氨酸形成及抗白血病作用

Cancer Res. 1988 Mar 15;48(6):1481-8.

7

Inhibition of folate-dependent enzymes by 7-OH-methotrexate.

Biochem Pharmacol. 1988 Sep 15;37(18):3531-4. doi: 10.1016/0006-2952(88)90709-5.

8

Effects on dihydrofolate reductase of methotrexate metabolites and intracellular folates formed following methotrexate exposure of human breast cancer cells.甲氨蝶呤代谢产物及人乳腺癌细胞暴露于甲氨蝶呤后形成的细胞内叶酸对二氢叶酸还原酶的影响。

Biochem Pharmacol. 1987 Jul 15;36(14):2416-8. doi: 10.1016/0006-2952(87)90612-5.

9

Analog specific aberrancies in antifolate inhibition of L1210 cell dihydrofolate reductase.抗叶酸对L1210细胞二氢叶酸还原酶抑制作用中的类似物特异性异常

Biochem Pharmacol. 1980 Dec;29(24):3293-8. doi: 10.1016/0006-2952(80)90306-8.

10

Inhibitory action of 10-deazaaminopterins and their polyglutamates on human thymidylate synthase.10-脱氮氨基蝶呤及其多聚谷氨酸对人胸苷酸合成酶的抑制作用。

Mol Pharmacol. 1986 Aug;30(2):149-53.

引用本文的文献

1

Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model.白细胞介素-6 通过降低 SLC19A1 表达调控甲氨蝶呤治疗关节炎的作用。

Arthritis Res Ther. 2012 Apr 30;14(2):R96. doi: 10.1186/ar3821.