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Effects on dihydrofolate reductase of methotrexate metabolites and intracellular folates formed following methotrexate exposure of human breast cancer cells.

作者信息

Drake J C, Allegra C J, Baram J, Kaufman B T, Chabner B A

出版信息

Biochem Pharmacol. 1987 Jul 15;36(14):2416-8. doi: 10.1016/0006-2952(87)90612-5.

DOI:10.1016/0006-2952(87)90612-5
PMID:2440441
Abstract
摘要

相似文献

1
Effects on dihydrofolate reductase of methotrexate metabolites and intracellular folates formed following methotrexate exposure of human breast cancer cells.甲氨蝶呤代谢产物及人乳腺癌细胞暴露于甲氨蝶呤后形成的细胞内叶酸对二氢叶酸还原酶的影响。
Biochem Pharmacol. 1987 Jul 15;36(14):2416-8. doi: 10.1016/0006-2952(87)90612-5.
2
Interaction of methotrexate polyglutamates and dihydrofolate during leucovorin rescue in a human breast cancer cell line (MCF-7).甲氨蝶呤多聚谷氨酸与二氢叶酸在亚叶酸钙解救过程中于人类乳腺癌细胞系（MCF-7）中的相互作用
Cancer Res. 1990 Jun 15;50(12):3574-8.
3
Rescue effect of exogenous reduced folates on methotrexate polyglutamylation and dihydrofolate reductase activity in L1210 cells.外源性还原型叶酸对L1210细胞中氨甲蝶呤多聚谷氨酸化及二氢叶酸还原酶活性的挽救作用。
Acta Biochim Pol. 1988;35(3):199-205.
4
Methotrexate polyglutamate synthesis by cultured human breast cancer cells.培养的人乳腺癌细胞中甲氨蝶呤多聚谷氨酸的合成
Proc Natl Acad Sci U S A. 1980 May;77(5):2919-22. doi: 10.1073/pnas.77.5.2919.
5
Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase.甲氨蝶呤多聚谷氨酸在人乳腺癌细胞中的细胞内药代动力学。4-氨基-10-甲基蝶酰谷氨酸4和4-氨基-10-甲基蝶酰谷氨酸5对二氢叶酸还原酶的选择性保留及较少的解离性结合。
J Clin Invest. 1983 Sep;72(3):773-8. doi: 10.1172/JCI111048.
6
Synthesis, binding and intracellular retention of methotrexate polyglutamates by cultured human breast cancer cells.
Adv Exp Med Biol. 1983;163:247-57. doi: 10.1007/978-1-4757-5241-0_19.
7
Reduction of oxidised folates by dihydrofolate reductase from methotrexate-resistant Lactobacillus casei.来自耐甲氨蝶呤干酪乳杆菌的二氢叶酸还原酶对氧化型叶酸的还原作用
Biochim Biophys Acta. 1977 Jun 10;482(2):261-71. doi: 10.1016/0005-2744(77)90240-6.
8
Inhibition of human dihydrofolate reductase by antifolyl polyglutamates.抗叶酸聚谷氨酸对人二氢叶酸还原酶的抑制作用。
Biochem Pharmacol. 1989 Feb 1;38(3):541-3. doi: 10.1016/0006-2952(89)90397-3.
9
Synthesis and retention of methotrexate polyglutamates by human small cell lung cancer.人小细胞肺癌对甲氨蝶呤多聚谷氨酸的合成与潴留
Biochem Pharmacol. 1984 May 15;33(10):1682-5. doi: 10.1016/0006-2952(84)90292-2.
10
The synthesis and retention of methotrexate polyglutamates in cultured human breast cancer cells.甲氨蝶呤多聚谷氨酸盐在培养的人乳腺癌细胞中的合成与保留
Ann N Y Acad Sci. 1982 Dec 10;397:184-92. doi: 10.1111/j.1749-6632.1982.tb43426.x.

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1
Diverse Inhibitors of De Novo Purine Synthesis Promote AICAR-Induced AMPK Activation and Glucose Uptake in L6 Myotubes.多种从头嘌呤合成抑制剂促进AICAR诱导的L6肌管中AMPK激活和葡萄糖摄取。
Biofactors. 2025 Jul-Aug;51(4):e70037. doi: 10.1002/biof.70037.
2
Breast cancer: insights in disease and influence of drug methotrexate.乳腺癌：疾病见解及甲氨蝶呤药物的影响
RSC Med Chem. 2020 May 28;11(6):646-664. doi: 10.1039/d0md00051e. eCollection 2020 Jun 1.
3
Low-dose methotrexate results in the selective accumulation of aminoimidazole carboxamide ribotide in an erythroblastoid cell line.
低剂量甲氨蝶呤导致红细胞样细胞系中氨甲酰咪唑核苷酸的选择性积累。
J Pharmacol Exp Ther. 2013 Oct;347(1):154-63. doi: 10.1124/jpet.113.206672. Epub 2013 Jul 25.
4
Pharmacokinetic study of methotrexate, folinic acid and their serum metabolites in children treated with high-dose methotrexate and leucovorin rescue.大剂量甲氨蝶呤及亚叶酸钙解救治疗儿童中甲氨蝶呤、亚叶酸钙及其血清代谢产物的药代动力学研究
Eur J Clin Pharmacol. 1990;39(4):377-83. doi: 10.1007/BF00315414.
5
Inhibition of 7-hydroxymethotrexate formation by amsacrine.安吖啶对7-羟基甲氨蝶呤形成的抑制作用。
Cancer Chemother Pharmacol. 1991;28(5):377-83. doi: 10.1007/BF00685693.