Visser Elizabeth, Milne Denis, Collacott Ian, McLernon David, Counsell Carl, Vickers Mark
Division of Applied Health Sciences, College of Life Sciences and Medicine, University of Aberdeen, Room 1:015, Polwarth Building, Foresterhill, Aberdeen AB252ZD, UK.
BMC Infect Dis. 2014 Mar 20;14:151. doi: 10.1186/1471-2334-14-151.
Infection with Epstein-Barr virus (EBV) is almost ubiquitous in humans and generally occurs at two ages: infantile, which is usually asymptomatic and associated with poorer socioeconomic conditions, and adolescent, which causes infectious mononucleosis (IM) in ~25% cases. The determinants of whether the infection causes IM remain uncertain. We aimed to evaluate seasonality and temporal trends in IM.
Data from all Monospot tests, used as a marker for IM, were collected from the Grampian population over 16 years.
Positive Monospot test results peaked at 17 years in females and 19 in males. Females had 16% more diagnoses, although 55% more tests. IM was ~38% more common in winter than summer. The annual rate of positive tests decreased progressively over the study period, from 174/100 000 (95% CI 171-178) in 1997 to 67/100 000 (95% CI 65-69) in 2012.
IM appears to be decreasing in incidence, which may be caused by changing environmental influences on immune systems. One such factor may be exposure to sunlight.Words 168.
The Medical Research Council and NHS Grampian-MS endowments.
爱泼斯坦-巴尔病毒（EBV）感染在人类中几乎普遍存在，通常发生在两个年龄段：婴儿期，通常无症状，且与较差的社会经济状况相关；青少年期，约25%的病例会引发传染性单核细胞增多症（IM）。感染是否会导致IM的决定因素仍不确定。我们旨在评估IM的季节性和时间趋势。
收集了格兰扁地区16年来所有用作IM标志物的嗜异性凝集试验的数据。
嗜异性凝集试验阳性结果在女性中于17岁达到峰值，在男性中于19岁达到峰值。女性的诊断病例多16%，尽管检测次数多55%。IM在冬季比夏季常见约38%。在研究期间，年度阳性检测率逐渐下降，从1997年的174/10万（95%置信区间171 - 178）降至2012年的67/10万（95%置信区间65 - 69）。
IM的发病率似乎在下降，这可能是环境对免疫系统的影响发生变化所致。其中一个因素可能是阳光照射。字数168。
医学研究理事会和NHS格兰扁 - MS捐赠基金。
