Resta L, Scordari M D, Mastrogiulio R S, Faggiano C, Sabatini L, Trimigliozzi F, Pascazio F, Loiudice L
Institute of Pathology, University of Bari, Italy.
Eur J Gynaecol Oncol. 1989;10(1):49-54.
Twenty-nine women were treated for endocervical adenocarcinoma in the University of Bari in the years 1975-1981. The histological type was "endocervical" or "mucinous" in 12 patients (41.4%), "endometrioid" in 12 (41.4%), "clear cell" in 2 (6.9%), "adenosquamous" in 2 (6.9%), and "serous" or "papillary" in 1. Foci of papillary and endometrioid metaplasia were present in 2 adenocarcinomas of endocervical type. The following histochemical methods were used: PAS reaction, PAS reaction with diastase predigestion, Bleu Alcian at pH 2.5 and pH 1, mucicarmine, Toluidine Bleu at 0.3%. The "endocervical" type adenocarcinoma showed mucicarmine positive and PAS positive, diastase resistant material in the whole cytoplasm. This material was not metachromatic and Bleu Alcian positive only in the well differentiated forms. In the "endometrial" adenocarcinoma only in the apex of the glandular cells was PAS positive diastase resistant, Alcian and mucicarmine positive. "Clear cell" and "adenosquamous" carcinomas showed only few cytoplasmatic PAS positive, diastase sensitive granules (= glycogen). No positivity was present in the "papillary" or "serous" carcinomas. Our results permit us to unify the histological and the histochemical patterns of the cervical adenocarcinomas and those of the similar forms of the endometrium and of the ovary, and stress the common müllerian origin of these neoplasms.
1975年至1981年期间，29名女性在巴里大学接受了宫颈腺癌治疗。组织学类型为“宫颈内膜样”或“黏液性”的有12例患者（41.4%），“子宫内膜样”的有12例（41.4%），“透明细胞”的有2例（6.9%），“腺鳞癌”的有2例（6.9%），“浆液性”或“乳头状”的有1例。2例宫颈内膜样腺癌存在乳头状和子宫内膜样化生灶。采用了以下组织化学方法：PAS反应、经淀粉酶预消化的PAS反应、pH值为2.5和pH值为1时的阿尔辛蓝、黏液卡红、0.3%甲苯胺蓝。“宫颈内膜样”型腺癌在整个细胞质中显示黏液卡红阳性和PAS阳性、淀粉酶抗性物质。这种物质不具有异染性，仅在高分化形式中阿尔辛蓝阳性。在“子宫内膜样”腺癌中，仅腺细胞顶端的PAS阳性、淀粉酶抗性、阿尔辛蓝和黏液卡红阳性。“透明细胞”和“腺鳞癌”仅显示少数细胞质PAS阳性、淀粉酶敏感颗粒（=糖原）。“乳头状”或“浆液性”癌无阳性表现。我们的结果使我们能够统一宫颈腺癌以及子宫内膜和卵巢相似形式的组织学和组织化学模式，并强调这些肿瘤共同的苗勒管起源。
