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CD8-predominant T-cell CNS infiltration accompanies GVHD in primates and is improved with immunoprophylaxis.

作者信息

Kaliyaperumal Saravanan, Watkins Benjamin, Sharma Prachi, Furlan Scott, Ramakrishnan Swetha, Giver Cynthia, Garcia Anapatricia, Courtney Cynthia, Knight Heather, Strobert Elizabeth, Elder Eric, Crenshaw Timothy, Blazar Bruce R, Waller Edmund K, Westmoreland Susan, Kean Leslie S

机构信息

New England Primate Research Center, Harvard Medical School, Southborough, MA.

出版信息

Blood. 2014 Mar 20;123(12):1967-9. doi: 10.1182/blood-2014-01-547612.

DOI:10.1182/blood-2014-01-547612
PMID:24652969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3962171/
Abstract
摘要

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GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression.同种异体移植后移植物抗宿主病：一种新型的、MHC 定义的恒河猴模型，确定了 CD28- CD8+ T 细胞在共刺激阻断和基于西罗莫司的免疫抑制期间突破 T 细胞增殖的储库。
Blood. 2010 Dec 9;116(24):5403-18. doi: 10.1182/blood-2010-06-289272. Epub 2010 Sep 10.
4
Therapeutic antibodies for autoimmunity and inflammation.自身免疫和炎症的治疗性抗体。
Nat Rev Immunol. 2010 May;10(5):301-16. doi: 10.1038/nri2761.
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beta2-integrins in demyelinating disease: not adhering to the paradigm.脱髓鞘疾病中的β2 整合素：不遵循范式。
J Leukoc Biol. 2010 Mar;87(3):397-403. doi: 10.1189/jlb.1009654. Epub 2009 Dec 9.
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Graft-versus-host disease of the CNS after allogeneic bone marrow transplantation.异基因骨髓移植后中枢神经系统的移植物抗宿主病
J Clin Oncol. 2009 Oct 20;27(30):e147-9. doi: 10.1200/JCO.2009.21.7919. Epub 2009 Aug 10.
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Central nervous system graft-versus-host disease presenting with granulomatous encephalitis.以肉芽肿性脑炎为表现的中枢神经系统移植物抗宿主病。
Bone Marrow Transplant. 2007 Jul;40(2):183-4. doi: 10.1038/sj.bmt.1705709. Epub 2007 May 14.
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