肝脏缺血再灌注损伤中的氧化还原疗法
Redox therapeutics in hepatic ischemia reperfusion injury.
作者信息
Patel Rakesh P, Lang John D, Smith Alvin B, Crawford Jack H
机构信息
Rakesh P Patel, Department of Pathology, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, United States.
出版信息
World J Hepatol. 2014 Jan 27;6(1):1-8. doi: 10.4254/wjh.v6.i1.1.
Abstract
Ischemia-reperfusion plays a major role in the injury experienced by the liver during transplantation. Much work has been done recently investigating the role of redox species in hepatic ischemia-reperfusion. As animal models are better characterized and developed, and more insights are gained into the pathophysiology of hepatic ischemia reperfusion injury in humans the questions into exactly how oxidants participate in this injury are becoming more refined. These questions include effects of cellular location, timing of injury, and ability of therapeutics to access this site are increasing our appreciation of the complexity of ischemia reperfusion and improving attempts to ameliorate its effects. In this review, we aim to discuss the various methods to alter redox chemistry during ischemia reperfusion injury and future prospects for preventing organ injury during hepatic ischemia reperfusion.
摘要
缺血再灌注在肝脏移植过程中所经历的损伤中起主要作用。最近，人们开展了大量工作来研究氧化还原物质在肝脏缺血再灌注中的作用。随着动物模型得到更好的表征和发展，并且对人类肝脏缺血再灌注损伤的病理生理学有了更多了解，关于氧化剂究竟如何参与这种损伤的问题也变得更加精确。这些问题包括细胞位置的影响、损伤时间以及治疗药物到达该部位的能力，这使我们更加认识到缺血再灌注的复杂性，并改进了减轻其影响的尝试。在本综述中，我们旨在讨论在缺血再灌注损伤期间改变氧化还原化学的各种方法以及预防肝脏缺血再灌注期间器官损伤的未来前景。
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