肝移植中的肝缺血再灌注损伤：机制与保护策略。
Hepatic ischemia-reperfusion injury in liver transplant setting: mechanisms and protective strategies.
作者信息
Rampes Sanketh, Ma Daqing
机构信息
Faculty of Life Sciences & Medicine, King's College London, London SE1 1U, UK.
Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, UK.
出版信息
J Biomed Res. 2019 Jul 28;33(4):221-234. doi: 10.7555/JBR.32.20180087.
Abstract
Hepatic ischemia-reperfusion injury is a major cause of liver transplant failure, and is of increasing significance due to increased use of expanded criteria livers for transplantation. This review summarizes the mechanisms and protective strategies for hepatic ischemia-reperfusion injury in the context of liver transplantation. Pharmacological therapies, the use of pre-and post-conditioning and machine perfusion are discussed as protective strategies. The use of machine perfusion offers significant potential in the reconditioning of liver grafts and the prevention of hepatic ischemia-reperfusion injury, and is an exciting and active area of research, which needs more study clinically.
摘要
肝缺血再灌注损伤是肝移植失败的主要原因，并且由于扩大标准供肝用于移植的使用增加而变得越来越重要。本综述总结了肝移植背景下肝缺血再灌注损伤的机制和保护策略。讨论了药物治疗、预处理和后处理的应用以及机器灌注作为保护策略。机器灌注在肝移植器官修复和预防肝缺血再灌注损伤方面具有巨大潜力，是一个令人兴奋且活跃的研究领域，需要更多的临床研究。
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