Monteiro Sofia B, Costa Antónia, Paiva Vera
Department of Obstetrics and Gynecology, São João Hospital, Porto, Portugal.
J Pediatr Adolesc Gynecol. 2012 Oct;25(5):e107-9. doi: 10.1016/j.jpag.2012.05.012.
Meigs syndrome is rare in women under 30 years of age and even more if associated with an elevated CA-125. In this case, malignancy was suspected and raised concerns about fertility preservation.
A 13-year-old girl presented with a 4-month amenorrhea, abdominal enlargement and dyspnea. Ultrasonography showed a 14-cm solid mass with ascites, bilateral pleural effusion and, analytically, elevated serum CA-125. Unilateral salpingo-oophorectomy was performed, with a 19 × 15 × 12 cm mass being disclosed from the right ovary. Final pathology diagnosed a mitotically active cellular ovarian fibroma (MACF), with no significant nuclear atypia.
MACF is a recent histopathologic entity. Despite the high count of mitotic figures, it is not associated with atypia, which contributes to favorable outcome. Although initial suspicions of malignancy, a conservative surgical intervention allowed fertility preservation. This was clinically appropriate and with no implications on survival and prognosis of these patients.
梅格斯综合征在30岁以下女性中罕见，若伴有CA - 125升高则更为罕见。在此病例中，怀疑为恶性肿瘤，并引发了对生育力保留的担忧。
一名13岁女孩出现4个月闭经、腹部增大和呼吸困难。超声检查显示有一个14厘米的实性肿块，伴有腹水、双侧胸腔积液，分析显示血清CA - 125升高。实施了单侧输卵管卵巢切除术，从右侧卵巢切除一个19×15×12厘米的肿块。最终病理诊断为有丝分裂活跃的细胞性卵巢纤维瘤（MACF），无明显核异型性。
MACF是一种新的组织病理学实体。尽管有丝分裂象数量较多，但它与异型性无关，这有助于获得良好的结果。尽管最初怀疑为恶性肿瘤，但保守的手术干预保留了生育能力。这在临床上是合适的，且对这些患者的生存和预后没有影响。
