Kumar Ambuj, Rajendran Vidya, Sethumadhavan Rao, Purohit Rituraj
Bioinformatics Division, School of Bio Sciences and Technology, Vellore Institute of Technology University, Vellore 632014, Tamil Nadu, India.
Curr Drug Targets. 2014 May;15(5):558-63. doi: 10.2174/1389450115666140321120315.
Centrosomes are the vital component of cell cycle progression pathway. Recent investigations have suggested their role in regulating the immune response system. Centrosome polarization delivers secretory granules to the immunological synapse (IS). The Cytotoxic T lymphocytes use a specific mechanism, controlled by centrosome delivery to the plasma membrane for delivering the secretory granules to the immunological synapse. Moreover, the polarization of centrioles to the immunological synapse directs secretion from cytolytic cells of innate as well as adaptive immune systems. Although the recent investigations have suggested their strong role in mediating the crucial events of immunological response, there are few discrepancies that are yet to be resolved. Furthermore, a clear picture of their molecular mechanism along with their cellular functions has not been reported. In this manuscript we have reviewed some important points that explain the importance of centrosomes in mediating the immunological signals and the delivery of lytic discharge from the cytotoxic and killer cells.
中心体是细胞周期进程途径的重要组成部分。最近的研究表明它们在调节免疫反应系统中发挥作用。中心体极化将分泌颗粒输送到免疫突触（IS）。细胞毒性T淋巴细胞使用一种特定机制，该机制由中心体向质膜的输送控制，用于将分泌颗粒输送到免疫突触。此外，中心粒向免疫突触的极化指导先天和适应性免疫系统的溶细胞的分泌。尽管最近的研究表明它们在介导免疫反应的关键事件中发挥着重要作用，但仍有一些差异有待解决。此外，尚未报道它们的分子机制及其细胞功能的清晰图景。在本手稿中，我们回顾了一些要点，这些要点解释了中心体在介导免疫信号以及细胞毒性和杀伤细胞的裂解性释放中的重要性。
