肥胖悖论、恶病质、衰弱与心力衰竭。
Obesity paradox, cachexia, frailty, and heart failure.
作者信息
Lavie Carl J, De Schutter Alban, Alpert Martin A, Mehra Mandeep R, Milani Richard V, Ventura Hector O
机构信息
Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, University of Queensland School of Medicine, 1514 Jefferson Highway, New Orleans, LA 70121-2483, USA; Cardiac Rehabilitation, Exercise Laboratories, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, University of Queensland School of Medicine, 1514 Jefferson Highway, New Orleans, LA 70121-2483, USA; Department of Preventive Medicine, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, University of Queensland School of Medicine, 1514 Jefferson Highway, New Orleans, LA 70121-2483, USA.
出版信息
Heart Fail Clin. 2014 Apr;10(2):319-26. doi: 10.1016/j.hfc.2013.12.002.
Overweight and obesity adversely affect cardiovascular (CV) risk factors and CV structure and function, and lead to a marked increase in the risk of developing heart failure (HF). Despite this, an obesity paradox exists, wherein those who are overweight and obese with HF have a better prognosis than their leaner counterparts, and the underweight, frail, and cachectic have a particularly poor prognosis. In light of this, the potential benefits of exercise training and efforts to improve cardiorespiratory fitness, as well as the potential for weight reduction, especially in severely obese patients with HF, are discussed.
超重和肥胖会对心血管（CV）危险因素以及CV结构和功能产生不利影响，并导致心力衰竭（HF）发生风险显著增加。尽管如此，肥胖悖论依然存在，即超重和肥胖的HF患者比体型较瘦的患者预后更好，而体重过轻、身体虚弱和恶病质患者的预后则特别差。鉴于此，本文将讨论运动训练的潜在益处以及提高心肺适能的努力，以及减重的可能性，尤其是对于重度肥胖的HF患者。
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