State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.
Institut für Physiologische Chemie, University Medical Center, Johannes Gutenberg University Mainz, Universität, Duesbergweg 6, 55099 Mainz, Germany.
Mater Sci Eng C Mater Biol Appl. 2014 May 1;38:227-34. doi: 10.1016/j.msec.2014.02.007. Epub 2014 Feb 12.
The in vitro degradation behavior of poly-L-lactide (PLLA), PLLA/aragonite pearl powder and PLLA/vaterite pearl powder scaffolds was investigated. The scaffolds were soaked in phosphate buffer solution (PBS) up to 200 days. Scanning electron microscopy (SEM), gel permeation chromatography (GPC), and differential scanning calorimetry (DSC) were used to observe any degradation of the scaffolds. Degradation behaviors such as changes in pH, porosity, bulk density, water absorption, weight loss and mechanical properties were discussed. The results show that a gradual increase of the pH in composite scaffolds can decrease the rate of hydrolysis of PLLA. PLLA/vaterite and PLLA/aragonite scaffolds have a similar degradation behavior but a slower rate of degradation than PLLA.
聚 L-乳酸（PLLA）、PLLA/文石珍珠粉和 PLLA/球霰石珍珠粉支架的体外降解行为进行了研究。支架在磷酸盐缓冲溶液（PBS）中浸泡长达 200 天。扫描电子显微镜（SEM）、凝胶渗透色谱（GPC）和差示扫描量热法（DSC）用于观察支架的任何降解情况。讨论了降解行为，如 pH 值、孔隙率、堆积密度、吸水率、失重和力学性能的变化。结果表明，复合支架中 pH 值的逐渐增加可以降低 PLLA 的水解速率。PLLA/球霰石和 PLLA/文石支架具有相似的降解行为，但降解速度比 PLLA 慢。
