Sato Takuma, Mori Shiro, Arai Yoichi, Kodama Tetsuya
Graduate School of Biomedical Engineering, Tohoku University, Aoba, Sendai, Miyagi, Japan; Department of Urology, Tohoku University Graduate School of Medicine, Aoba, Sendai, Miyagi, Japan.
Department of Oral and Maxillofacial Surgery, Tohoku University Hospital, Aoba, Sendai, Miyagi, Japan.
Ultrasound Med Biol. 2014 Jun;40(6):1237-49. doi: 10.1016/j.ultrasmedbio.2013.12.012. Epub 2014 Mar 20.
Intravenous chemotherapy is a therapeutic option for the treatment of lymph node metastasis, but the drugs often have difficulty accessing the lymphatic system. The aim of this study was to determine whether the combination of intralymphatic chemotherapy with ultrasound and nano-/microbubbles is active against tumors in mouse lymph nodes. Intralymphatic chemotherapy in mice with lymph nodes containing tumors was found to have a marked anti-tumor effect, compared with intravenous administration, and the addition of ultrasound combined with nano-/microbubbles enhanced the effect of the anti-cancer drug, but only when the drug was administered intralymphatically. Furthermore, decreases in the volumes and blood vessel densities of tumor-bearing lymph nodes are reliable measures of therapeutic effect, confirmed by histopathological evaluation. The main conclusion is that combining ultrasound with nano-/microbubbles and intralymphatic chemotherapy improves drug delivery to the lymphatic system and has a more potent anti-tumor effect.
静脉化疗是治疗淋巴结转移的一种治疗选择，但药物通常难以进入淋巴系统。本研究的目的是确定淋巴内化疗联合超声与纳米/微泡是否对小鼠淋巴结肿瘤有活性。与静脉给药相比，在含有肿瘤的淋巴结小鼠中进行淋巴内化疗具有显著的抗肿瘤作用，并且添加超声联合纳米/微泡可增强抗癌药物的作用，但仅当药物通过淋巴内给药时才有效。此外，荷瘤淋巴结体积和血管密度的降低是治疗效果的可靠指标，这已通过组织病理学评估得到证实。主要结论是，将超声与纳米/微泡和淋巴内化疗相结合可改善药物向淋巴系统的递送，并具有更强的抗肿瘤作用。
