Feigenson Keith A, Gara Michael A, Roché Matthew W, Silverstein Steven M
Department of Psychiatry, Robert Wood Johnson Medical School at Rutgers, The State University of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA.
Department of Psychiatry, Robert Wood Johnson Medical School at Rutgers, The State University of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA; University Behavioral Health Care at Rutgers, The State University of New Jersey, 671 Hoes Lane, Piscataway, NJ 08855, USA.
Psychiatry Res. 2014 Jun 30;217(1-2):1-8. doi: 10.1016/j.psychres.2014.03.005. Epub 2014 Mar 12.
A subgroup of people with schizophrenia is characterized by reduced organization in perception, thought, language, and motor functioning, and these impairments covary significantly. While this may reflect multiple expressions of an illness-related core processing impairment, it may also represent the extreme end of an organization-disorganization dimension that is found throughout the general population. In this view, disorganization is a modifying influence on illness expression. To obtain preliminary information on this hypothesis, we examined covariation of perceptual and cognitive organization in a non-patient sample. Subjects completed a battery of perceptual tasks with demonstrated sensitivity to schizophrenia and disorganization, and a battery of questionnaires examining cognitive organization. Our results indicated that level of perceptual organization ability, across multiple tasks, was associated with self-reported levels of cognitive organization on multiple measures. This is thus preliminary evidence for a common process affecting perceptual and cognitive organization in the general population, suggesting that disorganization may reflect a modifying influence mechanism, instead of an illness-related process, in schizophrenia.
精神分裂症患者的一个亚组表现为感知、思维、语言和运动功能的组织性降低，且这些损害显著共变。虽然这可能反映了与疾病相关的核心加工损害的多种表现，但它也可能代表了在普通人群中发现的组织-紊乱维度的极端情况。从这个角度来看，紊乱是对疾病表现的一种修饰性影响。为了获得关于这一假设的初步信息，我们在一个非患者样本中研究了感知和认知组织的共变情况。受试者完成了一系列对精神分裂症和紊乱具有敏感性的感知任务，以及一系列考察认知组织的问卷。我们的结果表明，在多个任务中，感知组织能力水平与多项测量中自我报告的认知组织水平相关。因此，这是关于影响普通人群感知和认知组织的共同过程的初步证据，表明在精神分裂症中，紊乱可能反映的是一种修饰性影响机制，而非与疾病相关的过程。
