高同型半胱氨酸血症是阿尔茨海默病在阿尔及利亚人群中的一个危险因素。

Hyperhomocysteinemia is a risk factor for Alzheimer's disease in an Algerian population.

机构信息

Département de Biologie Cellulaire et Moléculaire, Faculté des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumediene Alger, Algérie.

出版信息

Arch Med Res. 2014 Apr;45(3):247-50. doi: 10.1016/j.arcmed.2014.03.001. Epub 2014 Mar 20.

DOI:10.1016/j.arcmed.2014.03.001

PMID:24656904

Abstract

BACKGROUND AND AIMS

There is growing evidence that increased blood concentration of total homocysteine (tHcy) may be a risk factor for Alzheimer's disease (AD). The present study was conducted to evaluate the association of serum tHcy and other biochemical risk factors with AD.

METHODS

This is a case-control study including 41 individuals diagnosed with AD and 46 nondemented controls. Serum levels of all studied biochemical parameters were performed.

RESULTS

Univariate logistic regression showed a significant increase of tHcy (p = 0.008), urea (p = 0.036) and a significant decrease of vitamin B12 (p = 0.012) in AD group vs. controls. Using multivariate logistic regression, tHcy (p = 0.007, OR = 1.376) appeared as an independent risk factor predictor of AD. There was a significant positive correlation between tHcy and creatinine (p <0.0001). A negative correlation was found between tHcy and vitamin B12 (p <0.0001).

CONCLUSIONS

Our findings support that hyperhomocysteinemia is a risk factor for AD in an Algerian population and is also associated with vitamin B12 deficiency.

摘要

背景与目的

越来越多的证据表明，血液中总同型半胱氨酸（tHcy）浓度升高可能是阿尔茨海默病（AD）的一个危险因素。本研究旨在评估血清 tHcy 和其他生化危险因素与 AD 的关系。

方法

这是一项病例对照研究，包括 41 名确诊 AD 患者和 46 名非痴呆对照者。检测所有研究生化参数的血清水平。

结果

单因素 logistic 回归显示，AD 组的 tHcy（p = 0.008）、尿素（p = 0.036）水平显著升高，维生素 B12（p = 0.012）水平显著降低。使用多因素 logistic 回归，tHcy（p = 0.007，OR = 1.376）是 AD 的独立危险因素预测因子。tHcy 与肌酐呈显著正相关（p <0.0001），与维生素 B12 呈显著负相关（p <0.0001）。