Änkö Minna-Liisa
Department of Anatomy and Developmental Biology, Monash University, Level 3, Building 75, Wellington Road, Clayton, Melbourne, VIC 3800, Australia.
Semin Cell Dev Biol. 2014 Aug;32:11-21. doi: 10.1016/j.semcdb.2014.03.011. Epub 2014 Mar 19.
Serine-arginine rich splicing factors (SR proteins) are a family of RNA binding proteins that are essential for development in various model organisms. Although SR proteins are necessary for pre-mRNA splicing in metazoans, their binding is not limited to pre-RNA. SR proteins associate with various classes of RNAs, including intronless transcripts and non-coding RNAs, and regulate many processes during the gene expression pathway. Recent studies taking advantage of high-throughput sequencing and other genome-wide approaches have started to shed light into the distinct and overlapping roles of SR proteins in the regulation of gene expression in cells and have led to the identification of endogenous gene targets. These studies together with animal models where individual SR proteins have been depleted in specific tissues suggest that SR proteins may regulate distinct gene expression programmes through their interactions with RNAs and provide crosstalk between splicing and other regulatory processes.
富含丝氨酸 - 精氨酸的剪接因子（SR蛋白）是一类RNA结合蛋白，对多种模式生物的发育至关重要。尽管SR蛋白是后生动物前体mRNA剪接所必需的，但它们的结合并不局限于前体RNA。SR蛋白与各类RNA相关联，包括无内含子转录本和非编码RNA，并在基因表达途径中调节许多过程。最近利用高通量测序和其他全基因组方法进行的研究开始揭示SR蛋白在细胞基因表达调控中的独特和重叠作用，并导致了内源性基因靶点的鉴定。这些研究以及在特定组织中个别SR蛋白已被耗尽的动物模型表明，SR蛋白可能通过与RNA的相互作用调节不同的基因表达程序，并在剪接和其他调控过程之间提供相互作用。
