The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 Yanjiangxi Road, Guangzhou, Guangdong, China.
The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 Yanjiangxi Road, Guangzhou, Guangdong, China.
Exp Mol Pathol. 2014 Jun;96(3):284-91. doi: 10.1016/j.yexmp.2014.03.005. Epub 2014 Mar 20.
Substantial evidence suggests that the expansion of regulatory T cells (T(regs)) plays a pivotal role in immunological evasion of tumors. Recent studies have demonstrated that a majority of tumor cells overexpress B7-H1, and this overexpression is associated with poor disease prognosis. Although an increase of T(regs) and B7-H1 has been revealed in several malignancies, their correlation in gastric cancer has not been studied.
Tumor sections from 111 gastric cancer patients were stained for FOXP3 and B7-H1 by immunohistochemistry. The expression levels of these two molecules were statistically associated with various factors involved in disease progression and prognosis. The correlation between their expression levels was analyzed.
The infiltration of FOXP3(+) T(regs) and expression of B7-H1 were observed in gastric cancer tissues, and there was a highly significant correlation between these two molecules (P < 0.01). The expression of FOXP3(+) T(regs) and B7-H1 was associated with lymph node metastasis and the clinicopathological stage and prognosis of gastric cancer patients. The expression levels of these two determinants in patients with lymph node metastasis and an advanced clinicopathological stage were distinctly higher (P < 0.05). The patients with enhanced expression of FOXP3(+) T(regs) and B7-H1 exhibited a lower overall survival rate and a worse prognosis (P < 0.05).
Increased expression of FOXP3(+) T(regs) and B7-H1 was observed in gastric cancer tissues; the two molecules were closely correlated with each other, suggesting that they might be used as new biomarkers to predict the disease progression and prognosis. Combinatorial immunotherapeutic approaches based on depleting the T(regs) and blocking B7-H1 might improve therapeutic efficacy in gastric cancer.
大量证据表明调节性 T 细胞（Tregs）的扩增在肿瘤的免疫逃逸中起着关键作用。最近的研究表明，大多数肿瘤细胞过度表达 B7-H1，并且这种过表达与不良的疾病预后相关。尽管在几种恶性肿瘤中已经发现 Tregs 和 B7-H1 的增加，但它们在胃癌中的相关性尚未得到研究。
通过免疫组织化学法对 111 例胃癌患者的肿瘤切片进行 FOXP3 和 B7-H1 的染色。统计分析这两种分子的表达水平与疾病进展和预后相关的各种因素之间的相关性。分析它们表达水平之间的相关性。
FOXP3(+)Tregs 的浸润和 B7-H1 的表达在胃癌组织中观察到，并且这两种分子之间存在高度显著的相关性（P<0.01）。FOXP3(+)Tregs 和 B7-H1 的表达与淋巴结转移以及胃癌患者的临床病理分期和预后相关。在有淋巴结转移和临床病理分期较高的患者中，这两种决定因素的表达水平明显较高（P<0.05）。FOXP3(+)Tregs 和 B7-H1 表达增强的患者总生存率较低，预后较差（P<0.05）。
在胃癌组织中观察到 FOXP3(+)Tregs 和 B7-H1 的表达增加；这两种分子密切相关，表明它们可能被用作预测疾病进展和预后的新生物标志物。基于耗竭 Tregs 和阻断 B7-H1 的联合免疫治疗方法可能会提高胃癌的治疗效果。
