Teopompi Elisabetta, Tzani Panagiota, Aiello Marina, Gioia Maria Rosaria, Marangio Emilio, Chetta Alfredo
Respiratory Disease and Lung Function Unit, Department of Clinical and Experimental Medicine, University of Parma, Italy.
Respiratory Disease and Lung Function Unit, Department of Clinical and Experimental Medicine, University of Parma, Italy.
Respir Physiol Neurobiol. 2014 Jun 15;197:9-14. doi: 10.1016/j.resp.2014.03.002. Epub 2014 Mar 19.
We assessed the relationship between minute ventilation/carbon dioxide output (VE/VCO2) and ventilatory constraints during an incremental cardiopulmonary exercise testing (CPET) in patients with chronic obstructive pulmonary disease (COPD). Slope and intercept of the VE/VCO2 linear relationship, the ratios of inspiratory capacity/total lung capacity (IC/TLC) and of tidal volume (VT) over vital capacity (VTpeak/VC) and IC (VTpeak/IC) and over forced expiratory volume at 1st second (VTpeak/FEV1) at peak of exercise were measured in 52 COPD patients during a CPET. The difference peak-rest in end-tidal pressure of CO2 (PETCO2) was also measured. VE/VCO2 intercept showed a negative correlation with IC/TLC peak (p<0.01) and a positive one with VTpeak/FEV1 (p<0.01) and with PETCO2 peak-rest (p<0.01). VE/VCO2 slope was negatively related to VTpeak/VC, VTpeak/IC and VTpeak/FEV1 (all correlations p<0.05) and to PETCO2 peak-rest (p<0.01). In COPD, VE/VCO2 slope and intercept provide complementary information on the ventilatory limitation to exercise, as assessed by changes in the end-expiratory lung volume and in tidal volume excursion.
我们评估了慢性阻塞性肺疾病（COPD）患者在递增式心肺运动试验（CPET）期间，分钟通气量/二氧化碳排出量（VE/VCO2）与通气限制之间的关系。在52例COPD患者进行CPET期间，测量了运动峰值时VE/VCO2线性关系的斜率和截距、吸气容量/肺总量（IC/TLC）、潮气量（VT）与肺活量（VTpeak/VC）及IC（VTpeak/IC）的比值以及与第1秒用力呼气量（VTpeak/FEV1）的比值。还测量了呼气末二氧化碳分压（PETCO2）的运动峰值与静息值之差。VE/VCO2截距与IC/TLC峰值呈负相关（p<0.01），与VTpeak/FEV1呈正相关（p<0.01），与PETCO2运动峰值与静息值之差呈正相关（p<0.01）。VE/VCO2斜率与VTpeak/VC、VTpeak/IC和VTpeak/FEV1均呈负相关（所有相关性p<0.05），与PETCO2运动峰值与静息值之差呈负相关（p<0.01）。在COPD中，VE/VCO2斜率和截距可提供关于运动通气限制的补充信息，这可通过呼气末肺容积和潮气量变化来评估。
