RUNX2 在黑色素瘤细胞中过表达，并介导其迁移和侵袭。
RUNX2 is overexpressed in melanoma cells and mediates their migration and invasion.
机构信息
Rutgers Cancer Institute of New Jersey, Department of Medicine, Division of Medical Oncology - Rutgers, The State University of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USA.
Rutgers Cancer Institute of New Jersey, Department of Surgery, Division of Surgical Oncology, Rutgers, The State University of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USA.
出版信息
Cancer Lett. 2014 Jun 28;348(1-2):61-70. doi: 10.1016/j.canlet.2014.03.011. Epub 2014 Mar 18.
In the present study, we investigated the role of the transcription factor RUNX2 in melanomagenesis. We demonstrated that the expression of transcriptionally active RUNX2 was increased in melanoma cell lines as compared with human melanocytes. Using a melanoma tissue microarray, we showed that RUNX2 levels were higher in melanoma cells as compared with nevic melanocytes. RUNX2 knockdown in melanoma cell lines significantly decreased Focal Adhesion Kinase expression, and inhibited their cell growth, migration and invasion ability. Finally, the pro-hormone cholecalciferol reduced RUNX2 transcriptional activity and decreased migration of melanoma cells, further suggesting a role of RUNX2 in melanoma cell migration.
在本研究中，我们研究了转录因子 RUNX2 在黑色素瘤发生中的作用。我们证明与正常人黑素细胞相比，转录活性 RUNX2 的表达在黑素瘤细胞系中增加。使用黑素瘤组织微阵列，我们表明与神经黑色素细胞相比，RUNX2 水平在黑素瘤细胞中更高。在黑素瘤细胞系中敲低 RUNX2 显著降低粘着斑激酶的表达，并抑制其细胞生长、迁移和侵袭能力。最后，前激素胆钙化醇降低 RUNX2 的转录活性并减少黑素瘤细胞的迁移，进一步表明 RUNX2 在黑素瘤细胞迁移中的作用。
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