Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Int J Cancer. 2013 Mar 15;132(6):1260-71. doi: 10.1002/ijc.27964. Epub 2012 Dec 19.
The Runt-related transcription factors (RUNX) belong to an ancient family of metazoan genes involved in developmental processes. Through multiple protein-interacting partners, RUNX proteins have been implicated in diverse signaling pathways and cellular processes. The frequent inactivation of RUNX genes in cancer indicates crucial roles for RUNX in tumor suppression. This review discusses the abilities of RUNX proteins, in particular RUNX3, to integrate oncogenic signals or environmental cues and to initiate appropriate tumor suppressive responses.
Runt 相关转录因子 (RUNX) 属于参与发育过程的后生动物基因的古老家族。通过多种蛋白质相互作用伙伴，RUNX 蛋白已被牵连到多种信号通路和细胞过程中。RUNX 基因在癌症中的频繁失活表明 RUNX 在肿瘤抑制中起着至关重要的作用。本文讨论了 RUNX 蛋白（特别是 RUNX3）整合致癌信号或环境线索并启动适当的肿瘤抑制反应的能力。
