Scapaticci Rosa, Bellizzi Gennaro, Catapano Ilaria, Crocco Lorenzo, Bucci Ovidio Mario
IEEE Trans Biomed Eng. 2014 Apr;61(4):1071-9. doi: 10.1109/TBME.2013.2293839.
Magnetic nanoparticles-enhanced microwave imaging has been recently proposed to overcome the limitations of conventional microwave imaging methods for breast cancer monitoring. In this paper, we discuss how to tackle the linear inverse scattering problem underlying this novel technique in an effective way. In particular, our aim is to minimize the required a priori patient-specific information, avoid occurrence of false positives, and keep the computational burden low. By relying on an extensive numerical analysis in realistic conditions, we show that the method can provide accurate and reliable images without information on the inner structure of the inspected breast and with an only rough knowledge of its shape. Notably, this allows moving to an offline stage the computationally intensive part of the image formation procedure. In addition, we show how to appraise the total amount of magnetic contrast agent targeted in the tumor.
最近有人提出利用磁性纳米颗粒增强微波成像技术来克服传统微波成像方法在乳腺癌监测方面的局限性。在本文中，我们讨论了如何以有效的方式解决这一新技术背后的线性逆散射问题。具体而言，我们的目标是尽量减少所需的先验患者特定信息，避免出现假阳性，并保持较低的计算负担。通过在实际条件下进行广泛的数值分析，我们表明该方法无需关于被检查乳房内部结构的信息，仅需对其形状有大致了解，就能提供准确可靠的图像。值得注意的是，这使得图像形成过程中计算量较大的部分可以转移到离线阶段。此外，我们还展示了如何评估靶向肿瘤的磁性造影剂总量。
