根除幽门螺杆菌对早期胃癌内镜切除术后异时性胃癌预防的疗效。
Efficacy of Helicobacter pylori eradication for the prevention of metachronous gastric cancer after endoscopic resection for early gastric cancer.
作者信息
Jang Jae Young, Chun Hoon Jai
机构信息
Jae Young Jang, Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul 136-705, South Korea.
出版信息
World J Gastroenterol. 2014 Mar 21;20(11):2760-4. doi: 10.3748/wjg.v20.i11.2760.
Helicobacter pylori (H. pylori) plays an important role in gastric carcinogenesis, as the majority of gastric cancers develop from H. pylori-infected gastric mucosa. The rate of early gastric cancer diagnosis has increased in Japan and Korea, where H. pylori infection and gastric cancer are highly prevalent. Early intestinal-type gastric cancer without concomitant lymph node metastasis is usually treated by endoscopic resection. Secondary metachronous gastric cancers often develop because atrophic mucosa left untreated after endoscopic treatment confers a high risk of gastric cancer. The efficacy of H. pylori eradication for the prevention of metachronous gastric cancer remains controversial. However, in patients who undergo endoscopic resection of early gastric cancer, H. pylori eradication is recommended to suppress or delay metachronous gastric cancer. Careful and regularly scheduled endoscopy should be performed to detect minute metachronous gastric cancer after endoscopic resection.
幽门螺杆菌（H. pylori）在胃癌发生过程中起着重要作用，因为大多数胃癌是由感染幽门螺杆菌的胃黏膜发展而来。在幽门螺杆菌感染和胃癌高度流行的日本和韩国，早期胃癌的诊断率有所提高。无淋巴结转移的早期肠型胃癌通常通过内镜切除进行治疗。继发性异时性胃癌经常发生，因为内镜治疗后未治疗的萎缩性黏膜会带来较高的胃癌风险。幽门螺杆菌根除预防异时性胃癌的疗效仍存在争议。然而，对于接受早期胃癌内镜切除的患者，建议进行幽门螺杆菌根除治疗以抑制或延缓异时性胃癌的发生。内镜切除后应进行仔细且定期的内镜检查，以检测微小的异时性胃癌。
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