Mulder N H, Sleijfer D T, de Vries E G, Schraffordt Koops H, Samson M J, Willemse P H
Department of Internal Medicine, University Hospital Groningen, The Netherlands.
J Cancer Res Clin Oncol. 1989;115(1):93-5. doi: 10.1007/BF00391607.
Thirty-one patients with disseminated malignant melanoma were treated with a combination chemotherapy of bleomycin, dacarbazine and vindesine. Five complete responses, and five partial remissions occurred. One patient survived for over 2 years without evidence of disease. This combination of drugs may give better results, as far as complete recovery and long-term survival are concerned, than single-agent therapy with dacarbazine.
31例播散性恶性黑色素瘤患者接受了博来霉素、达卡巴嗪和长春地辛联合化疗。出现了5例完全缓解和5例部分缓解。1例患者存活超过2年且无疾病证据。就完全康复和长期生存而言，这种联合用药可能比单用达卡巴嗪治疗效果更好。
